Royal College of Surgeons in Ireland
|As first author||0|
|As last author||27|
Arnold D K Hill(29)
Fiona T Bane(9)
Elaine W Kay(7)
Aisling M Redmond(6)
Bryan T Hennessy(5)
E W McDermott(4)
Ann M Hopkins(3)
Helen O McCarthy(3)
... and 27 others
These arethe8 unique sources for Leonie S Young's 42 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.
|Ireland -> Dublin City University||2|
|Ireland -> Dublin City University -> PubMed||2|
|Ireland -> National University of Ireland Galway||1|
|Ireland -> National University of Ireland Galway -> PubMed||1|
|Ireland -> Royal College of Surgeons in Ireland||30|
|Ireland -> Royal College of Surgeons in Ireland -> PubMed||25|
|Ireland -> University College Dublin||9|
|Ireland -> University College Dublin -> PubMed||9|
A method of diagnosing metastatic potential of a breast cancer in an individual with breast cancer is described. The method comprises a step of assaying a breast cancer tumour sample from the patient for expression of ADAM22, wherein expression of ADAM22 correlates with increased potential for metastasis compared with a patient who is ADAM22 negative. The invention also describes an agent for use in the treatment of metastatic breast cancer in a patient, in which the agent is selected from LGI1 protein (SEQ ID NO:1) and an LGI1 peptide mimic capable of mimicking the ADAM22 binding activity of LGI1 by binding to the LGI1 binding domain of ADAM22 (SEQ ID NO: 4) and which is capable of inhibiting migration of endocrine resistant breast cancer cells.
A method of assessing recurrence status in a breast cancer patient comprises a step of assaying a biological sample from the patient for a level of a biomarker selected from Sl00ss or HOX-ClI, wherein positive detection of one or both of the biomarkers is indicative of a positive recurrence status. Suitably, the method is a method of prognosis of poor disease free survival in a breast cancer patient, wherein positive detection of one or both of the biomarkers is indicative of poor disease survival. The method may also be a method of diagnosis of recurrence, wherein positive detection of circulating Sl00ss is a diagnostic variable of recurrence. The method of diagnosis is carried out on a patient who is undergoing first line therapy and/or a patient who has had surgery to remove a primary breast tumour.
Clicking through these tabs will give you a wealth of further insights into this expert through their commonly used topics, the evolution of their expertise, their collaborators and their publications.
Here is a quick breakdown of this expert's publication history
If this is the expert you have been looking for, simply click here to make contact.