Trinity College Dublin
|As first author||43|
|As last author||40|
Aedín M Minogue(8)
Brian A. Lawlor(6)
Róisín M McManus(5)
Ian H Robertson(4)
Eric J. Downer(3)
Luke Anthony John O'Neill(3)
Orla M Finucane(3)
Joanna E. McHugh Power(2)
Mieszko M Wilk(2)
Daniel G W Johnston(1)
... and 11 others
These arethe4 unique sources for Marina Annetta Lynch's 75 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.
|Ireland -> National College Ireland||5|
|Ireland -> Trinity College Dublin||69|
|Ireland -> Trinity College Dublin -> PubMed||11|
|Ireland -> University College Cork||3|
Described is the novel finding that IL-1 F5 (IL-1 delta) and polypeptides derived therefrom bind to the receptor SIGIRR, with this binding interaction serving to modulate the immune response by stimulation the production of the cytokine IL-4. This induces an anti-inflammatory immune response. It has been further shown that PPARgamma is a key mediator in downstream signalling from SIGIRR following activation by the IL-1 F5 ligand. Modulation of the immune response occurs following binding of SIGIRR by IL-1 F5 in neuronal tissue and according methods for the treatment of neurodegenerative diseases are described.
Described is the novel finding that the administration of filamentous haemagglutinin (FHA) results in the maintenance of long term potentiation (LTP) . Moreover, the administration of FHA, through the modulation of inflammatory cytokine levels in the brain, can prevent the loss, and in some cases, can induce reversion to, normal levels of LTP in the brain. Further, where cognitive function may be impaired or diminished, for example in an aged animal or individual, FHA can be administered to reverse that impairment.
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