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Marina Annetta Lynch

Institution

Trinity College Dublin

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Subjects

Biochemistry

Psychiatry

Details
Publications 80
As first author 43
As last author 40
Unique topics 349
Collaborations 31
Patents 2
Sources 4
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2019
2018
2017
2016
2015
2014
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2012
2011
Earlier
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2019
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2012
2011
Earlier

2019

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.
2019

Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming
2019

Systemic inflammatory markers and sources of social support among older adults in the Memory Research Unit cohort
2019

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages
2018

A shift to glycolysis accompanies the inflammatory changes in PBMCs from individuals with an IQ-discrepant memory
2018

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
2017

Evidence that a metabolic shift towards glyclyosis in PBMCs may provide the basis of a biomarker of early cognitive dysfunction
2017

FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation.
2017

Inflammatory markers in plasma treated monocytes and metabolic changes as a novel blood biomarker assay for early cognitive dysfunction
2017

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
2016

Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease.
2016

Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis.
2016

Systemic inflammatory markers and sources of social support among older adults in the Memory Research Unit cohort
2015

α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
2015

Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli.
2015

Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli
2015

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice
2015

T Cells-Protective or Pathogenic in Alzheimer's Disease?
2014

Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice
2014

How dependent is synaptic plasticity on microglial phenotype?
2014

Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages.
2014

Innate IFN-γ promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages.
2014

Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.
2014

Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β
2014

α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
2013

Amyloid-beta-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE.
2013

Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells.
2013

Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
2013

Glial Activation in A?PP/PS1 Mice is Associated with Infiltration of IFN?-Producing Cells.
2013

IFN-? Production by Amyloid ?-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease.
2013

Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory
2013

Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased A? accumulation and microglial activation.
2013

Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction.
2013

Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice.
2013

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice.
2013

The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon.
2013

The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.
2013

The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner.
2013

Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β
2012

Activation of the P2X₇ receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1.
2012

Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
2012

CD200 fusion protein decreases microglial activation in the hippocampus of aged rats
2012

Dok2 mediates the CD200Fc attenuation of A?-induced changes in glia.
2012

LPS-induced release of IL-6 from glia modulates production of IL-1? in a JAK2-dependent manner.
2012

Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP.
2012

Rosiglitazone improves spatial memory and decreases insoluble A?(1-42) in APP/PS1 mice.
2012

The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability.
2012

The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation.
2012

The impact of aging on the brain - risk, resilience and repair
2011

A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
2011

Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.
2011

Analysis of the impact of CD200 on neurodegeneration
2011

Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
2011

IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice
2011

Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases
2011

Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice.
2011

Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation.
2011

Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress.
2011

The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation
2010

Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells
2010

Age-related neuroinflammatory changes negatively impact on neuronal function.
2010

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
2010

SIGIRR modulates the inflammatory response in the brain
2009

Age-related neuroinflammatory changes negatively impact on neuronal function.
2009

Bimodal magnetic-fluorescent nanostructures for biomedical applications
2009

Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro.
2009

Neuroinflammatory changes increase the impact of stressors on neuronal function.
2009

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
2007

CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.
2005

Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines
2005

Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus.
2004

Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus
2003

Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
2001

The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK
2001

Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination

These arethe4 unique sources for Marina Annetta Lynch's 75 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> National College Ireland 5
Ireland -> Trinity College Dublin 69
Ireland -> Trinity College Dublin -> PubMed 11
Ireland -> University College Cork 3
Mar 28, 2007

COMPOSITIONS AND METHODS RELATING TO THE MODULATION OF AN IMMUNE-MEDIATED RESPONSE
+
Oct 18, 2006

USE OF FILAMENTOUS HEMAGGLUTININ FOR THE TREATMENT OF COGNITIVE DYSFUNCTION AND NEURODEGENERATIVE DISORDERS
+

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