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Noel G McElvaney

Institution

Royal College of Surgeons in Ireland

Contact

Subjects

Biochemistry

Microbiology

Details
Publications 194
As first author 5
As last author 116
Unique topics 933
Collaborations 112
Patents 1
Sources 12
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2018
2017
2016
2015
2014
2013
2012
2011
2010
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2018
2017
2016
2015
2014
2013
2012
2011
2010
Earlier

2018

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications.
2018

Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity.
2018

The Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus
2018

The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals.
2017

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB.
2017

Brief Report: Genetic Variation of the α1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis.
2017

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95).
2017

European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α
2017

Glycosylation Repurposes Alpha-1 Antitrypsin for Resolution of Community-acquired-pneumonia.
2017

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.
2017

Pulmonary alveolar proteinosis.
2017

Reply.
2017

Risk factors for totally implantable venous access device-associated complications in cystic fibrosis.
2017

X Chromosome Encoded MicroRNAs are Functionally Increased in Cystic Fibrosis Monocytes.
2016

5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency.
2016

Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.
2016

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences.
2016

Determining rates of smoking cessation advice delivered during hospitalisation and smoking cessation rates 3 months post discharge: a two-hospital survey
2016

Exploring the views of healthcare professionals on increasing smoking cessation advice for patients.
2016

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing.
2016

Inhaled hypertonic saline for cystic fibrosis: reviewing the potential evidence for modulation of neutrophil signalling and function.
2016

Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE).
2016

Quantitative disease progression model of α-1 proteinase inhibitor therapy on computed tomography lung density in patients with α-1 antitrypsin deficiency.
2016

The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency.
2016

The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis.
2016

α1-Antitrypsin deficiency.
2015

Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis.
2015

Chitinase activation in patients with fungus-associated cystic fibrosis lung disease.
2015

Diagnosing α1-antitrypsin deficiency: how to improve the current algorithm.
2015

Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.
2015

New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity
2015

Short-chain Fatty Acids Cause an IL-8 Response in Cystic Fibrosis Airways via Increased GPR41.
2015

Smoking, attitudes to smoking and provision of smoking cessation advice in two teaching hospitals in Ireland: do smoke-free policies matter?
2015

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity.
2015

The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling.
2015

The Role of Short-Chain Fatty Acids, Produced by Anaerobic Bacteria, in the Cystic Fibrosis Airway.
2015

The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis.
2015

The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.
2015

The efficacy and safety of inhaled human α-1 antitrypsin in people with α-1 antitrypsin deficiency-related emphysema.
2015

The impact of smoke exposure on the clinical phenotype of alpha-1 antitrypsin deficiency in Ireland: exploiting a national registry to understand a rare disease.
2015

Tumor necrosis factor-α driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment.
2015

Unusual Acute Sequelae of α1-Antitrypsin Deficiency: A Myriad of Symptoms With One Common Cure.
2015

miR-17 overexpression in cystic fibrosis airway epithelial cells decreases interleukin-8 production.
2015

miR-CATCH: microRNA capture affinity technology.
2015

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6.
2014

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.
2014

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.
2014

Fungi in the cystic fibrosis lung: bystanders or pathogens?
2014

Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung.
2014

Identification and characterisation of eight novel SERPINA1 Null mutations.
2014

Identification and characterisation of eight novel SERPINA1 null mutations.
2014

Immunoevasive Aspergillus virulence factors.
2014

Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function.
2014

Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium.
2014

Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow - up in ANCA - associated vasculitis.
2014

The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity.
2014

The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.
2014

The role and importance of glycosylation of acute phase proteins with focus on alpha-1 antitrypsin in acute and chronic inflammatory conditions.
2014

Therapeutic aerosol bioengineering of siRNA for the treatment of inflammatory lung disease by TNFα gene silencing in macrophages.
2014

miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency.
2014

miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production.
2014

miR-CATCH: microRNA capture affinity technology.
2014

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6.
2013

A platelet dense-granule secretion defect may lead to a muted inflammatory cell mobilization response in Cystic Fibrosis patients.
2013

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis.
2013

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis.
2013

Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.
2013

Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease.
2013

Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease.
2013

Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique.
2013

Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium.
2013

Outcome in patients with cystic fibrosis liver disease.
2013

Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ΔF508 cystic fibrosis airway epithelium.
2012

A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.
2012

A survey of the prevalence of smoking and smoking cessation advice received by inpatients in a large teaching hospital in Ireland.
2012

Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency.
2012

Demodex-associated bacterial proteins induce neutrophil activation
2012

Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis
2012

Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis.
2012

Endothelial progenitor cells in mothers of low-birthweight infants: a link between defective placental vascularization and increased cardiovascular risk?
2012

Hypertonic saline in treatment of pulmonary disease in cystic fibrosis.
2012

Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?
2012

The CF-ABLE score: a novel clinical prediction rule for prognosis in patients with cystic fibrosis.
2012

The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis.
2012

The role of TIM-containing molecules in airway disease and their potential as therapeutic targets.
2012

Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.
2011

A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.
2011

A survey of the prevalence of smoking and smoking cessation advice received by inpatients in a large teaching hospital in Ireland.
2011

Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent.
2011

Demodex-associated bacterial proteins induce neutrophil activation.
2011

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.
2011

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations.
2011

In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.
2011

Measurement of the unfolded protein response (UPR) in monocytes.
2011

Measurement of the unfolded protein response (UPR) in monocytes.
2011

Mechanisms of protein misfolding in conformational lung diseases.
2011

Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis.
2011

Pleural fluid analysis: standstill or a work in progress?
2011

Pulmonary Inflammation in Cystic Fibrosis: Impact of Innate Immunity and Estrogen
2011

Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.
2011

The effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model.
2011

The involvement of glycosaminoglycans in airway disease associated with cystic fibrosis.
2011

The prevalence of alpha-1 antitrypsin deficiency in Ireland
2011

The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency.
2010

17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor.
2010

Alpha-1 antitrypsin deficiency.
2010

Candida species in cystic fibrosis: A road less travelled.
2010

Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency.
2010

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.
2010

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.
2010

Gain of function effects of Z alpha-1 antirypsin
2010

High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations.
2010

Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor
2010

MicroRNAs in inflammatory lung disease--master regulators or target practice?
2010

Protein misfolding and obstructive lung disease.
2010

Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway.
2010

Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.
2010

Sputum Candida albicans presages FEV₁ decline and hospital-treated exacerbations in cystic fibrosis.
2010

TLR3 Sensing of Viral Infection
2010

The cystic fibrosis neutrophil: a specialized yet potentially defective cell.
2010

The effect of liposome encapsulation on the pharmacokinetics of recombinant secretory leukocyte protease inhibitor (rSLPI) therapy after local delivery to a guinea pig asthma model.
2010

Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response
2010

Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response.
2010

miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression.
2010

miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression.
2009

A dry powder formulation of liposome-encapsulated recombinant secretory leukocyte protease inhibitor (rSLPI) for inhalation: preparation and characterisation.
2009

Alpha-1 antitrypsin deficiency.
2009

Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease.
2009

Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia?
2009

Cystic fibrosis, common variable immunodeficiency and Aspergers syndrome: an immunological and behavioural challenge.
2009

Extubation versus tracheostomy in withdrawal of treatment-ethical, clinical, and legal perspectives.
2009

Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency
2009

Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency.
2009

IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
2009

LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline.
2009

Male fertility in cystic fibrosis.
2009

Predictive validity of measurements of clinical competence using the team objective structured bedside assessment (TOSBA): assessing the clinical competence of final year medical students.
2009

Predictive validity of measurements of clinical competence using the team objective structured bedside assessment (TOSBA): assessing the clinical competence of final year medical students.
2009

Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery.
2009

Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery.
2009

Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency.
2009

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8.
2008

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
2008

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
2008

Adult-onset nemaline myopathy presenting as respiratory failure.
2008

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.
2008

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
2008

Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation.
2008

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.
2008

Targeting neutrophil elastase in cystic fibrosis.
2008

Toll-like receptors as therapeutic targets in cystic fibrosis.
2008

Toll-like receptors as therapeutic targets in cystic fibrosis.
2007

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.
2007

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke.
2007

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke.
2007

Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression.
2007

Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression.
2007

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.
2007

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.
2007

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.
2007

Team Objective Structured Bedside Assessment (TOSBA): a novel and feasible way of providing formative teaching and assessment.
2007

The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses.
2006

Antimicrobial proteins and polypeptides in pulmonary innate defence.
2006

Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.
2006

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.
2006

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.
2005

Antimicrobial proteins and polypeptides in pulmonary innate defence.
2005

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.
2005

Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis.
2005

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide.
2005

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide.
2005

Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding.
2005

TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells.
2005

Toll-like receptor expression and function in airway epithelial cells.
2005

Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells.
2004

Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.
2004

Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.
2004

Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells.
2004

Smoking ban--made in Ireland, for home use and for export.
2004

Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant.
2003

Association of IL-10 polymorphism with severity of illness in community acquired pneumonia.
2003

Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins.
2003

Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells.
2002

Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils.
2002

Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis.
2002

Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia.
2002

Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination.
2002

Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia.
2001

Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin.
2001

Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor.
2001

Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium.
2000

Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8.
2000

Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity.
2000

Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis.

These arethe12 unique sources for Noel G McElvaney's 194 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Dublin City University 5
Ireland -> Dublin City University -> PubMed 5
Ireland -> Maynooth University 4
Ireland -> Maynooth University -> PubMed 1
Ireland -> Royal College of Surgeons in Ireland 183
Ireland -> Royal College of Surgeons in Ireland -> PubMed 132
Ireland -> TU Dublin (Blanchardstown Campus) 1
Ireland -> TU Dublin (Blanchardstown Campus) -> PubMed 1
Ireland -> TU Dublin (Tallaght Campus) 2
Ireland -> TU Dublin (Tallaght Campus) -> PubMed 2
Ireland -> Trinity College Dublin 2
Ireland -> University College Dublin 1
Apr 16, 2013

Selective isolation of a messenger RNA molecule having its cognate micro RNA molecules bound thereto
+

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