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Padraic Fallon

Institution

Trinity College Dublin

Contact

Subjects

Microbiology

Biochemistry

Details
Publications 154
As first author 57
As last author 70
Unique topics 829
Collaborations 163
Sources 16
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2020

Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor
2019

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β
2018

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A
2018

Helminth Modulation of Lung Inflammation
2018

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
2018

Innate lymphoid cells and parasites: Ancient foes with shared history
2018

MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
2018

Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion.
2018

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells
2018

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis
2017

A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance.
2017

Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis
2017

Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.
2017

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
2017

Helminth Modulation of Lung Inflammation.
2017

IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.
2017

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
2017

Innate lymphoid cells and parasites: Ancient foes with shared history.
2017

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
2017

Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.
2017

SIPPET: insights into factor VIII immunogenicity.
2017

Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2?months is associated with a lower risk of atopic dermatitis at 1?year
2017

The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses.
2017

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.
2016

Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis.
2016

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
2016

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.
2016

Hypoxia-dependent regulation of inflammatory pathways in immune cells
2016

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
2016

N-linked glycan sites within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.
2016

N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor.
2016

New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression.
2016

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.
2016

Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year
2016

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
2016

The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases.
2016

The helminth T2 RNase v1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism
2015

A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria.
2015

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.
2015

Bcl11b is essential for group 2 innate lymphoid cell development
2015

Functional conservation of an ancestral Pellino protein in helminth species.
2015

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
2015

IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.
2015

Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity - emerging roles in obesity, intestinal inflammation and cancer.
2015

Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
2015

Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis.
2015

PD-L1(hi) B cells are critical regulators of humoral immunity.
2015

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
2015

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation.
2015

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33 and group 2 innate lymphoid cell-dependent mechanism.
2015

Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells.
2015

Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
2014

A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner.
2014

Activated Factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine prodution from LPS-stimulated myeloid cells.
2014

Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.
2014

Bcl11b is essential for group 2 innate lymphoid cell development.
2014

Btk Regulates Macrophage Polarization in Response to Lipopolysaccharide
2014

Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo.
2014

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.
2014

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
2014

Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation.
2014

Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
2014

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion.
2014

MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C
2014

MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
2014

PD-L1hi B cells are critical regulators of humoral immunity.
2014

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
2014

The alarmin IL-33 promotes regulatory T-cell function in the intestine.
2014

The generation of regulatory B cells by helminth parasites.
2014

Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer.
2014

von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo.
2013

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
2013

Btk regulates macrophage polarization in response to lipopolysaccharide.
2013

Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.
2013

Helminth therapies: translating the unknown unknowns to known knowns.
2013

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
2013

Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent.
2013

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.
2013

MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.
2013

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice.
2013

Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.
2013

Pellino3 ubiquitinates RIP2 and mediates NOD2-induced signaling and protective effects in colitis
2013

Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
2013

Regulation of IL-1ß-induced NF-¿B by hydroxylases links key hypoxic and inflammatory signaling pathways.
2013

The Toll-like Receptor 3 L412F Polymorphism and Disease Progression in Idiopathic Pulmonary Fibrosis.
2013

The alarmin IL-33 promotes regulatory T-cell function in the intestine.
2013

The schistosoma granuloma: friend or foe?
2013

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects
2013

Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by ¿¿ T Cells.
2013

Ursodeoxycholic acid attenuates colonic epithelial secretory function.
2012

A Mineral Extract from red Algae Ameliorates Chronic Spontaneous Colitis in IL-10 Deficient Mice in a Mouse Strain Dependent Manner.
2012

Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
2012

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.
2012

Helminth therapies: Translating the unknown unknowns to known knowns.
2012

Innate type 2 cells and asthma.
2012

Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
2012

Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier.
2012

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.
2012

Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice.
2012

The schistosoma granuloma: friend or foe?
2012

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
2012

Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
2011

A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins
2011

Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide
2011

Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells
2011

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus
2011

Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.
2011

Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis.
2011

Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
2011

SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
2011

The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells.
2010

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
2010

Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide.
2010

An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia.
2010

C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide.
2010

Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
2010

Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment
2010

Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea.
2010

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
2010

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
2010

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
2009

Generation of parasite antigens for use in Toll-like receptor research.
2009

Helminth-derived immunomodulatory molecules.
2009

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
2009

The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection
2008

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.
2008

Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy
2008

Mitochondrial uncoupling protein 1 expression in thymocytes.
2008

The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection.
2007

Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease.
2007

Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy.
2007

Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism.
2007

Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice.
2007

Specific intracellular adhesion molecule-grabbing nonintegrin R1 is not involved in the murine antibody response to pneumococcal polysaccharides.
2007

Suppression of TH2-type allergic reactions by helminth infection.
2007

T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation.
2007

The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.
2006

Helminth-modified pulmonary response protects mice from allergen-induced airway hyper-responsiveness.
2006

Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion.
2006

Pathogen-derived immunomodulatory molecules: future immunotherapeutics?
2005

Identification of a functioning mitochondrial uncoupling protein 1 in thymus
2005

Lethal, neonatal icthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome
2005

Schistosoma mansoni secretes a chemokine binding protein with anti-inflammatory activity.
2004

Helminth infection protects mice from anaphylaxis via IL-10 producing B cells
2004

Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines
2004

SIGN-R1 contributes to protection against lethal pneumococcal infection in mice
2004

Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages
2003

Decoy receptors in the regulation of T Helper cell type 2 response
2002

Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
2002

IL-4 induces characteristic Th2 response even in the combined absence of IL-5, IL-9 and IL-13
2000

IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development
1999

Simultaneous disruption of Interleukin (IL)-4 and IL-13 defines individual roles in T Helper cell Type 2-mediated responses
1998

Alterations in cytochrome-c oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni.
1998

Impaired development of Th2 cells in IL-13-deficient mice

These arethe16 unique sources for Padraic Fallon's 154 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Dublin City University 2
Ireland -> Dublin City University -> PubMed 2
Ireland -> Dublin Institute of Technology 3
Ireland -> Dublin Institute of Technology -> PubMed 1
Ireland -> Maynooth University 8
Ireland -> Maynooth University -> PubMed 4
Ireland -> Royal College of Surgeons in Ireland 6
Ireland -> Royal College of Surgeons in Ireland -> PubMed 6
Ireland -> TU Dublin 2
Ireland -> TU Dublin (Tallaght Campus) 2
Ireland -> TU Dublin (Tallaght Campus) -> PubMed 1
Ireland -> Trinity College Dublin 134
Ireland -> Trinity College Dublin -> PubMed 56
Ireland -> University College Cork 1
Ireland -> University College Dublin 7
Ireland -> University College Dublin -> PubMed 4

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