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Paul F Kenna

Institution

Trinity College Dublin

Contact

Subjects

Biochemistry

Details
Publications 62
As first author 2
As last author 8
Unique topics 433
Collaborations 39
Patents 3
Sources 6
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2017
2016
2015
2014
2013
2012
2011
2010
2009
Earlier
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2017
2016
2015
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2012
2011
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2009
Earlier

2017

Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia.
2017

Target 5000: Target capture sequencing for inherited retinal degenerations
2016

Panel-Based population next-generation sequencing for inherited retinal degenerations
2016

microRNA regulatory circuits in a mouse model of inherited retinal degeneration.
2015

A novel homozygous truncating GNAT1 mutation implicated in retinal degeneration.
2015

Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(-/-) mouse.
2015

IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates.
2014

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.
2013

Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy.
2013

Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
2013

Mitochondrial disorders: aetiologies, models systems, and candidate therapies
2012

Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
2012

Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
2012

Mitochondrial disorders: aetiologies, models systems, and candidate therapies.
2011

C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa.
2011

Calpain and photoreceptor apoptosis.
2011

Gene-based therapies for dominantly inherited retinopathies.
2011

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.
2011

On further development of barrier modulation as a technique for systemic ocular drug delivery.
2011

Protein misfolding and potential therapeutic treatments in inherited retinopathies.
2011

Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa
2011

Systemic low-molecular weight drug delivery to pre-selected neuronal regions
2010

Loss of photoreceptor potential from retinal progenitor cell cultures, despite improvements in survival.
2010

Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)
2010

Protection of photoreceptors in a mouse model of RP10.
2010

Reversible and size-selective opening of the inner Blood-Retina barrier: a novel therapeutic strategy.
2010

Systemic low-molecular weight drug delivery to pre-selected neuronal regions.
2009

Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene.
2009

An experimental platform for systemic drug delivery to the retina
2009

Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy.
2008

RNAi-mediated reversible opening of the blood-brain barrier.
2008

Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
2008

Variation in the electroretinogram of C57BL/6 substrains of mouse.
2007

A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.
2007

Altered expression and interaction of adherens junction proteins in the developing OLM of the Rho(-/-) mouse.
2007

Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa.
2007

Development of strategies for conditional RNA interference.
2007

Reference gene selection for real-time rtPCR in human epidermal keratinocytes.
2007

Studies on Irish families with autosomal dominant retinitis pigmentosa, congenital stationary night blindness and on mouse models of inherited retinopathies
2006

RNAi-based suppression and replacement of rds-peripherin in retinal organotypic culture.
2005

Aberrant retinal tight junction and adherens junction protein expression in an animal model of autosomal dominant Retinitis pigmentosa: the Rho(-/-) mouse.
2004

On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa.
2004

RNAi of COL1A1 in mesenchymal progenitor cells
2003

Toward a gene therapy for dominant disease: validation of an RNA interference-based mutation-independent approach.
2002

Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds-peripherin gene
2002

On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention.
2002

Sensitivity of Photoreceptor-Derived Cell Line (661W) to Baculoviral p35, Z-VAD.FMK, and Fas-Associated Death Domain
2002

Validation in mesenchymal progenitor cells of a mutation-independent ex vivo approach to gene therapy for osteogenesis imperfecta
2000

Ribozyme-based therapeutic approaches for autosomal dominant retinitis pigmentosa.
1999

A mutation-independent therapeutic strategem for osteogenesis imperfecta.
1999

Retinitis pigmentosa and progressive sensorineural hearing loss caused by a C12258A mutation in the mitochondrial MTTS2 gene.
1997

Clinical and molecular genetic characterisation of a family segregating autosomal dominant retinitis pigmentosa and sensorineural deafness.
1997

Strategems in vitro for gene therapies directed to dominant mutations.
1996

Three keratin gene mutations account for the majority of dominant simplex epidermolysis bullosa cases within the population of Ireland.
1992

Autosomal dominant retinitis pigmentosa: a novel mutation at the peripherin/RDS locus in the original 6p-linked pedigree.
1992

Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family.
1991

A sequence polymorphism in the human peripherin/RDS gene.
1991

A three-base-pair deletion in the peripherin-RDS gene in one form of retinitis pigmentosa.
1991

Autosomal dominant retinitis pigmentosa: localization of a disease gene (RP6) to the short arm of chromosome 6.
1990

Autosomal dominant retinitis pigmentosa: linkage to rhodopsin and evidence for genetic heterogeneity.
1989

Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3.
1989

Autosomal dominant retinitis pigmentosa: exclusion of a gene from extensive regions of chromosomes 6, 13, 20, and 21.

These arethe6 unique sources for Paul F Kenna's 62 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Royal College of Surgeons in Ireland 2
Ireland -> Royal College of Surgeons in Ireland -> PubMed 2
Ireland -> Trinity College Dublin 59
Ireland -> Trinity College Dublin -> PubMed 43
Ireland -> University College Dublin 1
Ireland -> University College Dublin -> PubMed 1
Mar 18, 2010

COMPLEMENT PROTEINS
+
Oct 22, 2008

GENETIC SUPPRESSION AND REPLACEMENT
+
Aug 31, 2005

METHODS AND REAGENTS FOR TREATING DISEASE
+

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