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Paula Meleady

Institution

Dublin City University

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Subjects

Biochemistry

Microbiology

Details
Publications 115
As first author 10
As last author 20
Unique topics 548
Collaborations 111
Patents 2
Sources 9
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2019
2018
2017
2016
2015
2014
2013
2012
2011
Earlier
All
2019
2018
2017
2016
2015
2014
2013
2012
2011
Earlier

2019

Improvements in single‐use bioreactor film material composition leads to robust and reliable Chinese hamster ovary cell performance
2019

Proteogenomic Annotation of Chinese Hamsters Reveals Extensive Novel Translation Events and Endogenous Retroviral Elements.
2018

A Comparative Quantitative LC-MS/MS Profiling Analysis of Human Pancreatic Adenocarcinoma, Adjacent-Normal Tissue, and Patient-Derived Tumour Xenografts.
2018

A proteomic profiling dataset of recombinant Chinese hamster ovary cells showing enhanced cellular growth following miR-378 depletion.
2018

Acute exposure to organic and inorganic sources of copper: Differential response in intestinal cell lines.
2018

Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity.
2018

Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR.
2018

Depletion of endogenous miRNA-378-3p increases peak cell density of CHO DP12 cells and is correlated with elevated levels of ubiquitin carboxyl-terminal hydrolase 14.
2018

Improvements in single-use bioreactor film material composition leads to robust and reliable Chinese hamster ovary cell performance.
2018

Increased growth rate and productivity following stable depletion of miR-7 in a mAb producing CHO cell line causes an increase in proteins associated with the Akt pathway and ribosome biogenesis.
2018

Proteomic analysis of the sarcolemma-enriched fraction from dystrophic mdx-4cv skeletal muscle
2018

Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy
2018

Proteomic profiling of liver tissue from the
2018

Proteomic profiling of the mouse diaphragm and refined mass spectrometric analysis of the dystrophic phenotype.
2018

Rapid charge variant analysis of monoclonal antibodies to support lead candidate biopharmaceutical development.
2018

Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle
2018

Subproteomic profiling of sarcolemma from dystrophic
2018

The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture.
2018

Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq.
2017

Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift.
2017

Filter-Aided Sample Preparation (FASP) for Improved Proteome Analysis of Recombinant Chinese Hamster Ovary Cells.
2017

Glycosylation Repurposes Alpha-1 Antitrypsin for Resolution of Community-acquired-pneumonia.
2017

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.
2017

Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients.
2017

Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine.
2017

Phosphopeptide Enrichment and LC-MS/MS Analysis to Study the Phosphoproteome of Recombinant Chinese Hamster Ovary Cells.
2017

Proteomic analysis of the sarcolemma-enriched fraction from dystrophic mdx-4cv skeletal muscle.
2017

Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy
2017

Proteomic profiling of the dystrophin complex and membrane fraction from dystrophic mdx muscle reveals decreases in the cytolinker desmoglein and increases in the extracellular matrix stabilizers biglycan and fibronectin.
2017

Two-Dimensional Gel Electrophoresis and 2D-DIGE.
2016

Clinical Proteomics: Liquid Chromatography-Mass Spectrometry (LC-MS) Purification Systems.
2016

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles.
2016

Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics.
2016

Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy.
2016

Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact.
2016

Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome.
2016

Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment.
2016

The iron-responsive microsomal proteome of Aspergillus fumigatus
2015

Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers.
2015

Concurrent Label-Free Mass Spectrometric Analysis of Dystrophin Isoform Dp427 and the Myofibrosis Marker Collagen in Crude Extracts from mdx-4cv Skeletal Muscles.
2015

Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells.
2015

Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy.
2015

Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells.
2015

Proteomic analysis of dystrophin deficiency and associated changes in the aged mdx-4cv heart model of dystrophinopathy-related cardiomyopathy.
2015

Proteomic differences in recombinant CHO cells producing two similar antibody fragments.
2015

Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype.
2015

Simultaneous Pathoproteomic Evaluation of the Dystrophin-Glycoprotein Complex and Secondary Changes in the mdx-4cv Mouse Model of Duchenne Muscular Dystrophy.
2015

The iron-responsive microsomal proteome of Aspergillus fumigatus.
2014

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.
2014

Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer.
2014

Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.
2014

Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy.
2014

Identification and functional validation of RAD23B as a potential protein in human breast cancer progression.
2014

Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry.
2014

Label-free mass spectrometric analysis of the mdx-4cv diaphragm identifies the matricellular protein periostin as a potential factor involved in dystrophinopathy-related fibrosis.
2014

PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
2014

Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients.
2013

Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.
2013

PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.
2013

Proteomics in uveal melanoma.
2012

A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.
2012

Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did Not.
2012

Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate.
2012

MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3.
2012

The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines
2012

Transcriptomic analysis of clonal growth rate variation during CHO cell line development.
2011

2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time coursedependent remodelling in response to 14 consecutive days of endurance exercise training
2011

2D gel electrophoresis and mass spectrometry identification and analysis of proteins.
2011

2D-DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines
2011

A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.
2011

CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture.
2011

Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells.
2011

Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity.
2011

Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines.
2011

Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3.
2011

Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.
2011

Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics.
2010

2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training.
2010

2D-DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines.
2010

Clinical proteomics: liquid chromatography-mass spectrometry purification systems.
2010

Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7.
2010

Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines.
2010

Predicting cell-specific productivity from CHO gene expression.
2010

Recent advances in clinical proteomics using mass spectrometry.
2009

Identification of pancreatic cancer invasion-related proteins by proteomic analysis
2009

MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines.
2009

Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line.
2009

Strategies for analysing and improving the expression and quality of recombinant proteins made in mammalian cells.
2009

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8.
2008

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells
2008

Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis.
2008

Identification of pancreatic cancer invasion-related proteins by proteomic analysis.
2008

Proteomic Profiling of Secreted Proteins from CHO Cells Using Surface-Enhanced Laser Desorption Ionization Time-of-Flight Mass Spectrometry
2008

Proteomic analysis of conditioned media from glucose responsive and glucose non-responsive phenotypes reveals a panel of secreted proteins associated with beta cell dysfunction.
2008

Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol.
2007

2-D difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of ten specific proteins.
2007

Differential protein expression following low temperature culture of suspension CHO-K1 cells.
2007

Proteomic analysis of isolated membrane fractions from superinvasive cancer cells
2007

Proteomic approaches for serum biomarker discovery in cancer.
2007

Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line.
2007

Proteomic profiling of secreted proteins from CHO cells using Surface-Enhanced Laser desorption ionization time-of-flight mass spectrometry.
2007

Purification and identification of a 7.6-kDa protein in media conditioned by superinvasive cancer cells.
2007

Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2.
2006

Proteomic analysis of isolated membrane fractions from superinvasive cancer cells.
2006

Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes.
2006

Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress.
2003

Challenges in molecular analysis for individualized cancer therapy.
2003

Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines.
2001

Bromodeoxyuridine increases keratin 19 protein expression at a posttranscriptional level in two human lung tumor cell lines.
2001

Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines.
2001

Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness.
1999

Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines.
1998

Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties.
1998

Regulation of keratin and integrin gene expression in cancer and drug resistance.
1997

Serum-free cell growth and differentiation studies in cultured cell lines

These arethe9 unique sources for Paula Meleady's 115 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Dublin City University 98
Ireland -> Dublin City University -> PubMed 95
Ireland -> Maynooth University 23
Ireland -> Royal College of Surgeons in Ireland 4
Ireland -> Royal College of Surgeons in Ireland -> PubMed 3
Ireland -> Trinity College Dublin 5
Ireland -> University College Dublin 2
Ireland -> University College Dublin -> PubMed 1
Ireland -> University of Limerick 1
Dec 24, 2008

DIFFERENTIAL EXPRESSION PROFILING ANALYSIS OF CELL CULTURE PHENOTYPES AND USES THEREOF
+
Mar 20, 2008

Differential expression profiling analysis of cell culture phenotypes and the uses thereof
+

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