Dublin City University
|As first author||0|
|As last author||7|
Aoife G Cotter(1)
John S Lambert(1)
... and 7 others
These arethe7 unique sources for Peter O'Gorman's 15 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.
|Ireland -> Dublin City University||9|
|Ireland -> Dublin City University -> PubMed||9|
|Ireland -> Maynooth University||3|
|Ireland -> TU Dublin (Tallaght Campus)||2|
|Ireland -> TU Dublin (Tallaght Campus) -> PubMed||2|
|Ireland -> University College Dublin||3|
|Ireland -> University College Dublin -> PubMed||3|
A method of predicting response to thalidomide, or thalidomide analogs, in an individual with cancer, especially cancers for which thalidomide has been implicated as a treatment, such as Multiple Myeloma (MM) employs one or more of a panel of biomarkers that have been shown to be differentially expressed in cancer patients that respond to thalidomide (hereafter "Responders") relative to cancer patients that do not respond to thalidomide (hereafter "Non-responders). The method involves assaying a biological sample from the individual to determine the abundance of at least three biomarkers including Vitamin-D binding protein precursor(VDB) (Sequence ID 1) and Serum amyloid A protein (SAA) (Sequence ID 3), and at least one of beta-2-microglobulin (B2M) (Sequence ID 4), Haptoglobin (Hp) precursor (fragment) (Sequence ID 5), and zinc-alpha-2- glycoprotein (ZAG) (Sequence ID 2). Correlation of the abundance value for the at least three biomarkers with a reference abundance value from a Responder or Non-responder enables predication of response to thalidomide for the patient.
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