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Shane J O'Neill

Institution

Royal College of Surgeons in Ireland

Contact

Subjects

Biochemistry

Microbiology

Details
Publications 84
As first author 2
As last author 18
Unique topics 616
Collaborations 60
Sources 7
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2017
2016
2014
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2012
2011
2010
2009
2008
Earlier
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2017
2016
2014
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2012
2011
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2008
Earlier

2017

Death by suicide at the Ward level in Northern Ireland.
2016

The 2015 National Survey of Breeding Hen Harrier in Ireland
2014

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.
2014

Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow - up in ANCA - associated vasculitis.
2014

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies.
2014

miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency.
2013

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis.
2013

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis.
2013

Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease.
2013

Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease.
2013

Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique.
2013

Recurring pulmonary hamartomas: cause for concern?
2012

Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis
2012

Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis.
2011

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.
2011

Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis.
2011

Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.
2010

17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor.
2010

Alpha-1 antitrypsin deficiency.
2010

Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency.
2010

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.
2010

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.
2010

Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor
2010

Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.
2010

Sputum Candida albicans presages FEV₁ decline and hospital-treated exacerbations in cystic fibrosis.
2010

miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression.
2010

miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression.
2009

Alpha-1 antitrypsin deficiency.
2009

Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease.
2009

Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia?
2009

Extubation versus tracheostomy in withdrawal of treatment-ethical, clinical, and legal perspectives.
2009

IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
2009

LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline.
2009

Male fertility in cystic fibrosis.
2009

Panton Valentine leukocidin MSSA leading to multi-organ failure.
2009

Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency.
2009

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8.
2008

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
2008

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
2008

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.
2008

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
2008

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.
2007

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.
2007

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke.
2007

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke.
2007

Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression.
2007

Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression.
2007

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.
2007

Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression.
2007

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.
2006

Antimicrobial proteins and polypeptides in pulmonary innate defence.
2006

Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.
2006

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.
2006

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.
2005

Antimicrobial proteins and polypeptides in pulmonary innate defence.
2005

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.
2005

Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis.
2005

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide.
2005

Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide.
2005

Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding.
2005

TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells.
2005

Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells.
2004

Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.
2004

Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.
2004

Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells.
2004

Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant.
2003

Association of IL-10 polymorphism with severity of illness in community acquired pneumonia.
2003

Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins.
2003

Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells.
2002

Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils.
2002

Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis.
2002

Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia.
2002

Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination.
2002

Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia.
2001

A Val193Met mutation in GPIIIa results in a GPIIb/IIIa receptor with a constitutively high affinity for a small ligand.
2001

Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin.
2001

Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor.
2001

Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium.
2000

Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8.
2000

Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis.
2000

The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity.
1999

Nutritional, respiratory, and psychological effects of recombinant human growth hormone in patients undergoing abdominal aortic aneurysm repair.
1998

Irish Thoracic Society: Proceeds of Annual Scientific Meeting held Friday & Saturday 8th & 9th November, 1996
1998

Pathogen-free granulomatous diseases of the central nervous system.

These arethe7 unique sources for Shane J O'Neill's 84 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Maynooth University 1
Ireland -> Royal College of Surgeons in Ireland 80
Ireland -> Royal College of Surgeons in Ireland -> PubMed 57
Ireland -> Trinity College Dublin 3
Ireland -> Trinity College Dublin -> PubMed 1
Ireland -> University College Cork 1
Ireland -> University College Cork -> PubMed 1

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