Dublin City University
|As first author||8|
|As last author||110|
Malcolm R. Smyth(14)
Chandra K Dixit(10)
Paul J Conroy(8)
Denise A Egan(8)
Anthony J. Killard(7)
... and 74 others
These arethe13 unique sources for R O'Kennedy's 185 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.
|Ireland -> Dublin City University||173|
|Ireland -> Dublin City University -> PubMed||160|
|Ireland -> IT Tallaght||1|
|Ireland -> IT Tallaght -> PubMed||1|
|Ireland -> Maynooth University||1|
|Ireland -> Royal College of Surgeons in Ireland||2|
|Ireland -> Royal College of Surgeons in Ireland -> PubMed||2|
|Ireland -> Teagasc||5|
|Ireland -> Teagasc -> PubMed||3|
|Ireland -> Trinity College Dublin||2|
|Ireland -> Trinity College Dublin -> PubMed||2|
|Ireland -> University College Dublin||1|
|Ireland -> University College Dublin -> PubMed||1|
A method of predicting the likelihood of a patient with a solid tumor cancer or a metastasis thereof responding to cancer therapy comprises the steps of assaying a sample of the primary solid tumor or a local or distant metastasis thereof obtained from the patient to determine a level of expression of CerS5, and if an elevated CerS5 expression level is detected in the sample from the patient, then predicting a likelihood that the patient will have a positive clinical response to cancer therapy, or if a non-elevated CerS5 expression level is detected in the sample from the patient, then predicting a likelihood that the patient will have a negative clinical response to cancer therapy.
The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e. millions-billions) but with greater efficiency and shorter time.
A method of generating and isolating a recombinant high affinity anti-sialic acid antibody molecule comprises the steps of immunising a host with an immunogen comprising a conjugate of sialic acid and a carrier protein to generate an anti-sialic acid polyclonal serum, isolating a sample of RNA from the immunised avian host, and generating and screening of a library of recombinant antibody molecules from the RNA sample, and isolating a recombinant high affinity anti-sialic acid antibody molecule. The antibody molecule is selected from the group consisting of: whole antibodies
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