Royal College of Surgeons in Ireland
|As first author||6|
|As last author||49|
Denis C. Shields(12)
F E Murray(11)
P B Maguire(7)
Andrew O Maree(7)
Glen A Doherty(7)
Anthony P Fitzgerald(6)
Kevin B Nolan(5)
Elaine W Kay(5)
Eamonn S Molloy(4)
Colm J O'Brien(4)
K M Sheehan(3)
R P Murphy(3)
... and 37 others
These arethe7 unique sources for D J Fitzgerald's 97 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.
|Ireland -> Royal College of Surgeons in Ireland||77|
|Ireland -> Royal College of Surgeons in Ireland -> PubMed||74|
|Ireland -> Teagasc||1|
|Ireland -> Teagasc -> PubMed||1|
|Ireland -> Trinity College Dublin||1|
|Ireland -> University College Dublin||18|
|Ireland -> University College Dublin -> PubMed||18|
A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10
A method of detecting in an individual incomplete inhibition an enzyme involved in thrombus formation, especially platelet cyclooxygesane, is described. The method comprises the steps of obtaining from the individual a biological sample which contains the enzyme, adding an exogenous substrate for the enzyme to the sample to form a reaction mixture, and assaying the reaction mixture for any increase in a level of a metabolite of the enzyme. The method is especially suitable for detecting sub-optimal ASPIRIN inhibition in individuals undergoing ASPIRIN anti-thrombosis therapy. Kits for carrying out the method of the invention are also described.
A method of inhibiting platelet activation in an human subject comprises the step of treating the subject with an agent which has an effect of preventing or disrupting an association between a nucleotide sensitive chloride channel ICLn and a platelet specific Integrin alphaIIbbeta3. The agent may be an inhibitor of the nucleotide sensitive chloride channel ICLn or a ligand having at least a mM binding affinity for an amino acid sequence KVGFFKR, such as a peptide comprising the sequence AKFEEE or the sequence KVGAAKR.
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