Royal College of Surgeons in Ireland
|As first author||25|
|As last author||112|
T Clive Lee(45)
Garry P Duffy(32)
Tanya J Levingstone(24)
John P Gleeson(24)
Emmet M Thompson(15)
Matthew G Haugh(15)
Ciara M Murphy(13)
Grainne M Cunniffe(11)
Conor T Buckley(11)
Caroline M Curtin(11)
... and 90 others
These arethe15 unique sources for Fergal J O'Brien's 241 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.
|Ireland -> Dublin City University||4|
|Ireland -> Dublin City University -> PubMed||4|
|Ireland -> Dublin Institute of Technology||7|
|Ireland -> Dublin Institute of Technology -> PubMed||3|
|Ireland -> Maynooth University||1|
|Ireland -> Maynooth University -> PubMed||1|
|Ireland -> National University of Ireland Galway||7|
|Ireland -> National University of Ireland Galway -> PubMed||7|
|Ireland -> Royal College of Surgeons in Ireland||201|
|Ireland -> Royal College of Surgeons in Ireland -> PubMed||111|
|Ireland -> Trinity College Dublin||31|
|Ireland -> Trinity College Dublin -> PubMed||7|
|Ireland -> University College Cork||1|
|Ireland -> University College Dublin||5|
|Ireland -> University College Dublin -> PubMed||3|
A composite scaffold for use as a tissue engineering implant A composite scaffold for use in tissue engineering applications comprises a porous scaffold matrix comprising at least an organic material, a first microparticle preparation distributed in the scaffold matrix, and a second microparticle preparation distributed in the scaffold matrix. The first microparticle preparation comprises microparticles having a first polymeric microparticle matrix and a first active agent within the matrix such that the first active agent is capable of being released from the microparticle matrix/scaffold at a controlled rate. The second microparticle preparation comprises microparticles having a second microparticle matrix and a second active agent within the matrix such that the second active agent is capable of being released from the second microparticle matrix/scaffold at a controlled rate.
The invention relates to a method for producing a multi-layer collagen scaffold. The method generally comprises the steps of: preparing a first suspension of collagen and freezing or lyophilising the suspension to provide a first layer
A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA i n an acidic solution, lyophilising the suspension at a constant cooling rate until a desired final freezing temperature is reached to produce the compos ite scaffold, wherein the ratio of HA to collagen is at least 1 : 10 (w/w). Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprisin g a homogenous distribution of hydroxyapatite within a porous, collagen matr ix, wherein the ratio of HA to collagen is at least 1 : 10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressi ve stiffness of at least 0.3KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants, tissue engineering implants, maxillofacial bone graft substitute, dental bone graft substitute, cartilag e defect repair implant and osteochondral defect repair implant.
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