University College Cork
|As first author||15|
|As last author||2|
Dmitri B Papkovsky(32)
Ruslan I Dmitriev(12)
Anna V Golubeva(6)
Jochen H M Prehn(3)
Pavel V. Baranov(3)
Cormac T. Taylor(3)
Irina A Okkelman(3)
Dmitry E. Andreev(3)
Patrick B F O'Connor(3)
Martina M Yordanova(2)
John F Atkins(2)
Audrey M. Michel(2)
... and 26 others
These arethe5 unique sources for Alexander V Zhdanov's 37 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.
|Ireland -> Maynooth University||1|
|Ireland -> University College Cork||35|
|Ireland -> University College Cork -> PubMed||31|
|Ireland -> University College Dublin||2|
|Ireland -> University College Dublin -> PubMed||1|
The invention is based on the use of photoluminescent probes for intracellular sensing of oxygen, especially assaying intracellular oxygen concentration. The photoluminescent probe comprises a suspension of polymeric particles having an average diameter in the 20nm to 100nm range, formed from an amphiphilic cationic co-polymer which is oriented in the formed particle to provide a hydrophobic core and a hydrophilic shell. The probe includes a hydrophobic oxygen-sensitive photoluminescent dye such as Pt-tetrakis (pentafluorophenyl) porphine, PtPFPP embedded in the hydrophobic core of the particle, and the co-polymer includes quaternary ammonium groups which provide hydrophilic and cationic character to the particle shell. The photoluminescent probe, which in use is provided in the form of an aqueous suspension of probe, is incubated with live mammalian cells in a suitable growth medium for a period of time to allow the probe particles passively load into the cells. Oxygen can then be sensed by detecting a photoluminescent signal of the photoluminescent probe, which can be correlated with oxygen status, for example oxygen concentration or changes in oxygen concentration/levels, using existing techniques.
A method of assessing toxicity of a candidate agent to a sample of cells comprises the steps of providing a sample of cells, exposing the cells to the candidate agent for a suitable period of time, assaying the cells to measure data for at least one parameter of cellular function
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