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Cliona O'Farrelly

Institution

Trinity College Dublin

Contact

Subjects

Microbiology

Biochemistry

Details
Publications 147
As first author 50
As last author 67
Unique topics 782
Collaborations 154
Sources 14
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2019
2018
2017
2016
2015
2014
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2012
2011
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2019
2018
2017
2016
2015
2014
2013
2012
2011
Earlier

2019

Non-canonical inflammasome-mediated IL-1β production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent
2019

The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)-mediated induction of suppressor of cytokine signaling (SOCS)3
2019

β-Defensins: Farming the microbiome for homeostasis and health
2018

European Researchers? Night as a Learning Environment
2018

HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction
2018

Improved detection of biomarkers in cervico-vaginal mucus (CVM) from postpartum cattle
2018

Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of LiverResident NK Cells in Colorectal Liver Metastasis
2018

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
2018

Recombinant β-defensin 126 promotes bull sperm binding to bovine oviductal epithelia
2017

A dual targeted β-defensin and exome sequencing approach to identify, validate and functionally characterise genes associated with bull fertility
2017

A novel anti-viral role for STAT3 in IFN-α signalling responses.
2017

Comparative genomic identification and validation of beta-defensin genes in the Ovis aries genome
2017

Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome
2017

Depleted polymorphonuclear leukocytes in human metastatic liver reflect an altered immune microenvironment associated with recurrent metastasis.
2017

Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma.
2017

HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction.
2017

Profiling inflammatory biomarkers in cervico-vaginal mucus (CVM) postpartum: Potential early indicators of bovine clinical endometritis?
2017

Uterine natural killer cell progenitor populations predict successful implantation in women with endometriosis-associated infertility.
2016

A novel anti-viral role for STAT3 in IFN-α signalling responses.
2016

Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy.
2016

CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer.
2016

Cauda Epididymis-Specific Beta-Defensin 126 Promotes Sperm Motility but Not Fertilizing Ability in Cattle.
2016

Comparative genomic identification and expression profiling of a novel β-defensin gene cluster in the equine reproductive tract
2016

Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome.
2016

Disease Outcomes in a Cohort of Women Infected by Hepatitis C-Contaminated anti-D Immunoglobulin During 1970s.
2016

Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway.
2016

Liver immunology and its role in inflammation and homeostasis
2016

Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain.
2016

Sperm-Coating Beta-Defensin 126 Is a Dissociation-Resistant Dimer Produced by Epididymal Epithelium in the Bovine Reproductive Tract.
2016

The CD4(+) T cell methylome contributes to a distinct CD4(+) T cell transcriptional signature in Mycobacterium bovis-infected cattle.
2016

The Microenvironment of Visceral Adipose Tissue and Liver Alter Natural Killer Cell Viability and Function
2016

Tissue-resident Eomes(hi) T-bet(lo) CD56(bright) NK cells with reduced pro-inflammatory potential are enriched in the human adult liver.
2016

Tissue-resident Eomes(hi) T-bet(lo) CD56(bright) NK cells with reduced proinflammatory potential are enriched in the adult human liver
2015

Erratum to: ‘Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis’
2015

Increased uNK Progenitor Cells in Women With Endometriosis and Infertility are Associated With Low Levels of Endometrial Stem Cell Factor.
2015

Liver immunology and its role in inflammation and homeostasis.
2015

Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance?
2015

Natural Killer Cells: Key Players in Endometriosis.
2015

Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection.
2015

The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function.
2014

Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes.
2014

Bovine b946;-defensin gene family: Opportunities to improve animal health?
2014

Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue
2014

Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation.
2014

Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation.
2014

Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses.
2014

Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses.
2014

IFNL cytokines do not modulate human or murine NK cell functions
2014

In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients.
2014

In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients.
2014

Microrna regulation of bovine monocyte inflammatory and metabolic networks in an in Vivo infection model
2014

RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis.
2014

Reply to: "Dendritic cell subset composition in the human liver is more complex than it seems"
2014

The role of microRNAs in bovine infection and immunity
2014

Tissue-specific NK cell populations and their origin.
2013

A novel subclass of bovine β-defensins links reproduction and immunology.
2013

Bovine β-defensin gene family: opportunities to improve animal health?
2013

CD141(+) myeloid dendritic cells are enriched in healthy human liver.
2013

Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue.
2013

Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC).
2013

Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene
2013

Hepatitis C Virus targets the Interferon-¿ JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.
2013

IFNL cytokines do not modulate human or murine NK cell functions.
2013

Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection
2013

Receptor-mediated recognition of mycobacterial pathogens.
2013

Reply to: "Assessing the immune phenotype of Dendritic Cells in the Liver is more complex than it seems"
2013

miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling.
2012

Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production.
2012

Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing.
2012

Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows
2012

Next generation sequencing reveals the expression of a unique miRNA profile in response to a gram-positive bacterial infection.
2012

Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder.
2011

Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide
2011

Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation
2011

Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease
2011

EXPERIMENTAL STAPHYLOCOCCUS AUREUS INFECTION OF THE MAMMARY GLAND INDUCES REGION-SPECIFIC CHANGES IN INNATE IMMUNE GENE EXPRESSION
2011

Endometrial aspiration biopsy: a non-invasive method of obtaining functional lymphoid progenitor cells and mature natural killer cells.
2011

Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes
2011

Global gene expression analysis of chicken caecal response to Campylobacter jejuni
2011

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion.
2011

Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection.
2011

Preparation of Pre-Confluent Retinal Cells Increases Graft Viability In Vitro and In Vivo: A Mouse Model
2011

Reproductive tissue-specific expression profiling and genetic variation across a 19 gene bovine β-defensin cluster.
2011

Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV
2010

A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection
2010

Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide.
2010

Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships
2010

Experimental Staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression.
2010

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion.
2010

Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke.
2010

Risk factors for the development of depression in patients with Hepatitis C taking Interferon-alpha.
2010

Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11
2010

Technical note: Comparative analyses of the quality and yield of genomic DNA from invasive and noninvasive, automated and manual extraction methods.
2010

The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity
2009

CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis.
2009

Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships.
2009

Differential antimicrobial peptide gene expression patterns during early chicken embryological development
2009

Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus.
2009

Evidence of the adaptive evolution of immune genes in chicken
2009

Gene expression profiling of the host response to Mycobacterium bovis infection in cattle.
2009

Innate immune gene expression differentiates the early avian intestinal response between Salmonella and Campylobacter
2009

Microanatomy of the liver immune system.
2008

Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program.
2008

Differential antimicrobial peptide gene expression patterns during early chicken embryological development.
2008

Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta.
2008

Toll-like receptor and antimicrobial peptide expression in the bovine endometrium.
2007

CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver
2007

Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?
2007

Evolution, expression and effectiveness in a cluster of novel bovine beta-defensins.
2007

Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease.
2007

Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection.
2006

Detection and characterization of hemopoietic stem cells in the adult human small intestine.
2006

Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection.
2006

Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury.
2006

The effects of tumour necrosis factor-alpha and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis.
2005

Toxigenic C. difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical.
2004

Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken
2004

Cortisol does not mediate the suppressive effects of psychiatric morbidity on natural killer cell activity: a cross-sectional study of patients with early breast cancer
2004

Distinct subpopulations of gy T cells are present in normal and tumor-bearing human liv
2004

Diverse populations of T cells with NK cellreceptors accumulate in the human intestine inhealth and in colorectal cancer
2004

Evidence of Positively Selected Sites in Mammalian a-Defensins
2004

Evidence of positively selected sites in mammalian alpha-defensins.
2004

Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development.
2004

Interleukin 12 (IL-12) is increased in tumourbearing human liver and expands CD8C andCD56C T cells in vitro but not in vivo
2003

Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer.
2002

Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells.
2000

Serum haptoglobin: an objective indicator of experimentally-induced Salmonella infection in calves.
1999

Factors produced by activated leukocytes alter renal epithelial cell differentiation.
1999

High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
1998

Emergence of classic enteropathy after longstanding gluten sensitive oral ulceration.
1998

Just how inflamed is the normal gut?
1998

Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes.
1996

Absence of oats toxicity in adult coeliac disease.
1996

Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation?
1995

Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes.
1995

Effects of tumour necrosis factor-alpha on BrdU incorporation in cultured human enterocytes.
1994

Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum.
1992

Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain.
1988

Altered gastrointestinal immune response in sarcoidosis.
1987

Histological changes associated with wheat protein antibodies in the absence of villous atrophy.
1987

Humoral response to alpha gliadin as serological screening test for coeliac disease.
1987

Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel.
1986

Gliadin antibody detection in gluten enteropathy.
1986

Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma.
1984

Increased concanavalin A induced suppression in treated and untreated coeliac disease.
1983

Alpha gliadin antibody levels: a serological test for coeliac disease.
1982

Cellular response to alpha-gliadin in untreated coeliac disease.

These arethe14 unique sources for Cliona O'Farrelly's 147 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Dublin City University 4
Ireland -> Dublin City University -> PubMed 1
Ireland -> Dublin Institute of Technology 2
Ireland -> Dublin Institute of Technology -> PubMed 2
Ireland -> Galway-Mayo IT 1
Ireland -> Maynooth University 14
Ireland -> TU Dublin 1
Ireland -> Teagasc 22
Ireland -> Teagasc -> PubMed 10
Ireland -> Trinity College Dublin 107
Ireland -> Trinity College Dublin -> PubMed 33
Ireland -> University College Dublin 13
Ireland -> University College Dublin -> PubMed 13
Ireland -> University of Limerick 4

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