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David J Brayden

Institution

University College Dublin

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Subjects

Pharmacology

Veterinary

Details
Publications 97
As first author 20
As last author 64
Unique topics 596
Collaborations 57
Patents 1
Sources 14
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2020
2019
2018
2017
2016
2015
2014
2013
2012
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2020
2019
2018
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2016
2015
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2012
Earlier

2020

An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations when Combined with a Permeation Enhancer
2020

Investigations of Piperazine Derivatives as Intestinal Permeation Enhancers in Isolated Rat Intestinal Tissue Mucosae
2019

Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update
2019

Evaluation of Sucrose Laurate as an Intestinal Permeation Enhancer for Macromolecules: Ex Vivo and In Vivo Studies
2019

Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)
2019

Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies
2019

Stomaching drug delivery
2018

Effects of surfactant-based permeation enhancers on mannitol permeability, histology, and electrogenic ion transport responses in excised rat colonic mucosae
2018

Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation
2018

Labrasol® and Salts of Medium-chain Fatty Acids Can Be Combined in Low Concentrations to Increase the Permeability of a Macromolecule Marker Across Isolated Rat Intestinal Mucosae
2018

Local delivery of macromolecules to treat diseases associated with the colon
2018

Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin
2017

A comparison of three Peyer's patch "M-like" cell culture models: particle uptake, bacterial interaction, and epithelial histology.
2017

A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation.
2017

Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles.
2017

Editorial overview: New technologies: drug delivery and medical devices combinations, more than the sum of the parts
2017

Effects of surfactant-based permeation enhancers on mannitol permeability, histology, and electrogenic ion transport responses in excised rat colonic mucosae.
2017

Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models
2017

Labrasol
2017

Progress in the Formulation and Delivery of Somatostatin Analogues for Acromegaly
2017

Progress in the formulation and delivery of somatostatin analogs for acromegaly.
2017

Sodium caprate enables the blood pressure-lowering effect of Ile-Pro-Pro and Leu-Lys-Pro in spontaneously hypertensive rats by indirectly overcoming PepT1 inhibition.
2017

The effect of plant sterol-enriched turkey meat on cholesterol bio-accessibility during in vitro digestion and Caco-2 cell uptake.
2016

An Assessment of the Permeation Enhancer, 1-phenyl-piperazine (PPZ), on Paracellular Flux Across Rat Intestinal Mucosae in Ussing Chambers
2016

Coated minispheres of salmon calcitonin target rat intestinal regions to achieve systemic bioavailability: Comparison between intestinal instillation and oral gavage
2016

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials
2016

Development of a Non-Aqueous Dispersion to Improve Intestinal Epithelial Flux of Poorly Permeable Macromolecules.
2016

Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models.
2016

Hepatic gateways.
2016

Intestinal permeation enhancers for oral peptide delivery
2016

Introduction for the special issue on recent advances in drug delivery across tissue barriers.
2016

Nanoparticle passage through porcine jejunal mucus: Microfluidics and rheology.
2016

Oral delivery of peptides: opportunities and issues for translation.
2016

Oral delivery strategies for nutraceuticals: Delivery vehicles and absorption enhancers
2016

Safety concerns over the use of intestinal permeation enhancers: A mini-review
2016

The challenges and future of oral drug delivery: An interview with David Brayden.
2015

Development of nanotoxicology: implications for drug delivery and medical devices.
2015

High-content analysis for drug delivery and nanoparticle applications
2015

In vitro and in vivo preclinical evaluation of a minisphere emulsion-based formulation (SmPill®) of salmon calcitonin.
2015

Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol
2015

Stability, toxicity and intestinal permeation enhancement of two food-derived antihypertensive tripeptides, Ile-Pro-Pro and Leu-Lys-Pro.
2014

Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative.
2014

First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models.
2014

Formulation strategies to improve oral peptide delivery.
2014

High-content analysis for drug delivery and nanoparticle applications.
2014

Poly(Ethylene glycol)-based backbones with high peptide loading capacities.
2014

Poly(Ethylene glycol)-based backbones with high peptide loading capacities.
2014

Progress in the delivery of nanoparticle constructs: towards clinical translation.
2013

An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis
2013

Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer
2013

Opportunities for drug-delivery research in nutraceuticals and functional foods?
2013

The role of citric acid in oral peptide and protein formulations: Relationship between calcium chelation and proteolysis inhibition.
2012

An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis.
2012

Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer.
2012

CriticalSorb promotes permeation of flux markers across isolated rat intestinal mucosae and Caco-2 monolayers
2012

Evaluation of alkylmaltosides as intestinal permeation enhancers: comparison between rat intestinal mucosal sheets and Caco-2 monolayers.
2012

Mechanisms of Action of Zinc on Intestinal Epithelial Electrogenic Ion Secretion: Insights into its Anti-Diarrheal Actions
2012

Mechanisms of action of zinc on rat intestinal epithelial electrogenic ion secretion: insights into its antidiarrhoeal actions.
2012

The mycotoxin patulin increases colonic epithelial permeability in vitro.
2011

High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs
2011

Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET).
2011

Oral peptide delivery: prioritizing the leading technologies.
2011

PK/PD modelling of combed-shaped PEGylated salmon calcitonin conjugates of differing molecular weights
2011

Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity.
2010

Antibacterial effects of poly(2-(dimethylamino ethyl)methacrylate) against selected Gram-positive and Gram-negative bacteria
2010

Drug delivery systems in domestic animal species.
2010

High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures
2010

PK/PD Modelling of Comb-Shaped PEGylated Salmon Calcitonin Conjugates of differing molecular weights
2010

Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate
2010

The 2nd Annual Irish Drug Delivery Network Conference with UK and Ireland Controlled Release Society: advancing drug delivery.
2009

Antibacterial effects of poly(2-(dimethylamino ethyl)methacrylate) against selected gram-positive and gram-negative bacteria.
2009

Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies.
2009

Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae.
2009

Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin.
2009

Lymphocyte migration through the blood-brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and tumour necrosis factor (TNF)-alpha within the central nervous system (CNS): studies using an in vitro feline BBB model.
2009

Safety and efficacy of sodium caprate in promoting oral drug absorption : from in vitro to the clinic
2008

Advances in PEGylation of important biotech molecules: delivery aspects.
2008

Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate.
2008

Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers.
2008

Feline immunodeficiency virus infection: a valuable model to study HIV-1 associated encephalitis.
2008

Increased intestinal permeability in rats subjected to traumatic frontal lobe percussion brain injury.
2007

A tertiary amino-containing polymethacrylate polymer protects mucus-covered intestinal epithelial monolayers against pathogenic challenge.
2007

Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers.
2007

Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease.
2007

In vitro interactions between the oral absorption promoter, sodium caprate (C(10)) and S. typhimurium in rat intestinal ileal mucosae.
2007

Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro.
2006

Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae.
2006

Melittin as an epithelial permeability enhancer I: investigation of its mechanism of action in Caco-2 monolayers.
2006

Rat, ovine and bovine Peyer's patches mounted in horizontal diffusion chambers display sampling function.
2005

Growth and characterisation of a cell culture model of the feline blood-brain barrier.
2005

Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting.
2004

Apical membrane receptors on intestinal M cells: potential targets for vaccine delivery.
2004

Oral delivery of pathogens from the intestine to the nervous system.
2003

Controlled release technologies for drug delivery.
2001

Oral vaccination in man using antigens in particles: current status.
1995

Cultured human sweat gland epithelia: isolation of glands using neutral red.
1994

A distinctive electrophysiological signature from the Peyer's patches of rabbit intestine.

These arethe14 unique sources for David J Brayden's 97 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Dublin City University 1
Ireland -> Dublin City University -> PubMed 1
Ireland -> Dublin Institute of Technology 3
Ireland -> Dublin Institute of Technology -> PubMed 2
Ireland -> Royal College of Surgeons in Ireland 7
Ireland -> Royal College of Surgeons in Ireland -> PubMed 6
Ireland -> TU Dublin 1
Ireland -> TU Dublin (Tallaght Campus) 2
Ireland -> TU Dublin (Tallaght Campus) -> PubMed 2
Ireland -> Trinity College Dublin 5
Ireland -> Trinity College Dublin -> PubMed 3
Ireland -> University College Dublin 82
Ireland -> University College Dublin -> PubMed 47
Ireland -> University of Limerick 1
Apr 25, 2012

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