An object/test material interaction microti iridic device comprising a sample inlet adapted to receive a fluid sample comprising a plurality of objects, an outlet adapted to output the fluid sample from the device, at least one internal surface defining a flow cavity within the device, wherein the flow cavity extends between and is connected to the sample inlet and the outlet for flow of the fluid sample through the flow cavity, the flow cavity comprises a test area to which at least one test material is attached and which is situated in the flow cavity for flow of the fluid sample over the test area, and the flow cavity has an aspect ratio which, when the flow cavity is substantially filled by the fluid sample, provides a substantially constant shear force between the test area and the fluid sample flowing over the test area.

Use of a metal complex having the formula: [M(L1)a(L2)b(L3)c]-Xd-Pepe wherein M is a metal selected from osmium, ruthenium, rhodium, rhenium or copper

Related:

The invention relates to a method of screening a patient to identify and quantify risk of colorectal cancer, and thereby identify patients suitable for further invasive investigation such as a colonoscopy. The method employs auto-antibodies that are shown to correlate with colorectal cancer risk method and involves of assaying a biological sample from the individual for a combination of a plurality of biomarkers selected from SEQUENCE ID NO's: 1 to 12, where the combination of biomarkers is chosen such that detection of all biomarkers in the patient correlates to at least a 50% risk of the patient being positive for colorectal cancer. Detection of all of the combination of biomarkers indicates that the patient should undergo a colonoscopy. Kits for performing the method of the invention are also provided.

Related:

The invention relates to the peptides shown in Sequence ID Numbers 1 to 18 that have been found to be useful in modulating platelet activity, and modulating other types of cellular activity. The invention also relates to fragments, or analogues, of the peptides which retain the ability to modulate platelet activity.

A cyclic beta-hairpin peptidomimetic comprises a reverse turn such as a beta-turn, first and second adjacent anti-parallel beta-strands flanking the reverse turn, and a p-hairpin stabilising motif, wherein the first beta-strand includes an amino acid sequence which is capable of forming a continuous beta-sheet with at least a portion of a beta-3-strand from an Al domain of Von Willebrand Factor. Also disclosed is a method of treating or preventing a condition associated with thrombosis in a subject in need thereof which comprises administering to the subject a therapeutically effective amount of a cyclic beta-hairpin peptidomimetic according to the invention.