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Helen M. Roche

Institution

University College Dublin

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Subjects

Biochemistry

Details
Publications 105
As first author 2
As last author 57
Unique topics 545
Collaborations 111
Sources 13
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2020

Substantial inter-individual variations in insulin secretion and sensitivity across the glucometabolic spectrum
2018

Nutrition and physical activity countermeasures for sarcopenia: Time to get personal?
2017

Clustering high-dimensional mixed data to uncover sub-phenotypes: joint analysis of phenotypic and genotypic data
2017

Effect of Dietary Lipids on Endotoxemia Influences Postprandial Inflammatory Response.
2017

Exploring the Links between Diet and Health in an Irish Cohort: A Lipidomic Approach
2017

Fatty Acids and NLRP3 Inflammasome-Mediated Inflammation in Metabolic Tissues.
2017

Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort
2017

Mediterranean Diet, Glucose Homeostasis and Inflammasome Genetic Variants: The CORDIOPREV Study.
2017

Nutritional modulation of metabolic inflammation.
2017

Processed red meat contribution to dietary patterns and the associated cardio-metabolic outcomes.
2017

Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice.
2017

Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures
2017

Weighted Gene Co-Expression Network Analysis Identifies Gender Specific Modules and Hub Genes Related to Metabolism and Inflammation in Response to an Acute Lipid Challenge.
2016

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome.
2016

Association of the tumor necrosis factor-alpha promoter polymorphism with change in triacylglycerol response to sequential meals.
2016

Clustering high-dimensional mixed data to uncover sub-phenotypes: joint analysis of phenotypic and genotypic data.
2016

Consumer Assessment of Unmet Needs in the Development of Targeted and Appropriate Novel Food for the Over Sixty Fives
2016

Dietary fat quantity and quality modifies advanced glycation end products metabolism in patients with metabolic syndrome.
2016

Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood.
2016

Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation.
2016

Metabolic Inflammation-Differential Modulation by Dietary Constituents.
2016

Uncovering Factors Related to Pancreatic Beta-Cell Function.
2015

A casein hydrolysate protects mice against high-fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling.
2015

Body mass index mediates inflammatory response to acute dietary challenges.
2015

Dietary fat may modulate adipose tissue homeostasis through the processes of autophagy and apoptosis.
2015

Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome.
2015

High Density Lipoprotein Proteomic Composition, and Not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat Diets.
2015

Insulin resistance determines a differential response to changes in dietary fat modification on metabolic syndrome risk factors: the LIPGENE study.
2015

Low-grade inflammation, diet composition and health: current research evidence and its translation.
2015

Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study.
2015

Monounsaturated Fatty Acid-Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome-Mediated IL-1β Secretion and Insulin Resistance Despite Obesity.
2015

Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome.
2014

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality.
2014

Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women.
2014

Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation.
2014

Peripheral blood mononuclear cells as in vivo model for dietary intervention induced systemic oxidative stress.
2014

Protein Quality and the Protein to Carbohydrate Ratio within a High Fat Diet Influences Energy Balance and the Gut Microbiota In C57BL/6J Mice
2014

Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids.
2014

Relationship between the lipidome, inflammatory markers and insulin resistance.
2013

Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses.
2013

Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers.
2013

Habitual dietary intake impacts on the lipidomic profile.
2013

Identification of differential responses to an oral glucose tolerance test in healthy adults.
2013

Impact of geographical region on urinary metabolomic and plasma fatty acid profiles in subjects with the metabolic syndrome across Europe: the LIPGENE study.
2013

Interactions between differential fatty acids and inflammatory stressors-impact on metabolic health.
2013

Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I deficient mice.
2013

Macrophage migration inhibitory factor deficiency ameliorates high-fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis.
2013

PBMCs reflect the immune component of the WAT transcriptome-Implications as biomarkers of metabolic health in the postprandial state.
2013

Protein quality and the protein to carbohydrate ratio within a high fat diet influences energy balance and the gut microbiota in C57BL/6J mice.
2013

Top Single Nucleotide Polymorphisms Affecting Carbohydrate Metabolism in Metabolic Syndrome: From the LIPGENE Study.
2013

Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes.
2013

Within-person variation in the postprandial lipemic response of healthy adults.
2012

Bioactivity in Whey Proteins Influencing Energy Balance
2012

Diet and Metabolic Syndrome: An Overview.
2012

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance.
2012

High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults.
2012

Lipoxin A4 attenuates adipose inflammation.
2012

Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies.
2012

Nutritional status, genetic susceptibility, and insulin resistance--important precedents to atherosclerosis.
2012

Obesity and body fat classification in the metabolic syndrome: impact on cardiometabolic risk metabotype.
2012

The relationship between BMI and metabolomic profiles: a focus on amino acids.
2012

The relationship between aerobic fitness level and metabolic profiles in healthy adults.
2011

Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk.
2011

Divergent effects of a CLA-enriched beef diet on metabolic health in ApoE(-/-) and ob/ob mice.
2011

Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA.
2011

Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue.
2011

Impact of leucine on energy balance.
2011

Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.
2011

Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice.
2011

Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy.
2011

The SGBS cell strain as a model for the in vitro study of obesity and cancer.
2011

Transcriptomic coordination in the human metabolic network reveals links between n-3 fat intake, adipose tissue gene expression and metabolic health.
2010

ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat.
2010

Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components.
2010

Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome.
2010

Conjugated linoleic acid and inflammatory cell signalling.
2010

Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome.
2010

Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome--LIPGENE: a European randomized dietary intervention study.
2010

Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk.
2010

Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome.
2010

High-molecular-weight adiponectin is selectively reduced in women with polycystic ovary syndrome independent of body mass index and severity of insulin resistance.
2010

Lipoprotein subclass patterns in women with polycystic ovary syndrome (PCOS) compared with equally insulin-resistant women without PCOS.
2010

Metabolic and hormonal aspects of polycystic ovary syndrome: the impact of diet.
2010

Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ.
2010

The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA.
2009

A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4.
2009

Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome.
2009

Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome.
2009

Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults.
2009

Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.
2009

Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults.
2009

NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids.
2008

Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages.
2008

Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2.
2008

Gene-nutrient interactions in the metabolic syndrome.
2008

Session 2: Personalised nutrition. Transcriptomic signatures that have identified key features of metabolic syndrome.
2007

Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue.
2007

The potential role of olive oil-derived MUFA in insulin sensitivity.
2006

Conjugated linoleic acid: a functional nutrient in the different pathophysiological components of the metabolic syndrome?
2006

Genetic and nutrient determinants of the metabolic syndrome.
2005

Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
2005

The metabolic syndrome: the crossroads of diet and genetics.
2004

Dietary lipids and gene expression.
2002

Chronic but not acute treatment with conjugated linoleic acid (CLA) isomers (trans-10, cis-12 CLA and cis-9, trans-11 CLA) affects lipid metabolism in Caco-2 cells.
2001

Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids.

These arethe13 unique sources for Helen M. Roche's 105 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Dublin City University 2
Ireland -> Dublin City University -> PubMed 2
Ireland -> TU Dublin (Tallaght Campus) 1
Ireland -> TU Dublin (Tallaght Campus) -> PubMed 1
Ireland -> Teagasc 9
Ireland -> Teagasc -> PubMed 5
Ireland -> Trinity College Dublin 12
Ireland -> Trinity College Dublin -> PubMed 10
Ireland -> University College Cork 5
Ireland -> University College Cork -> PubMed 3
Ireland -> University College Dublin 77
Ireland -> University College Dublin -> PubMed 72
Ireland -> University of Limerick 1

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