Type

Journal Article

Authors

Marian Tsanov
Karl Deisseroth
Charu Ramakrishnan
Harold M McNamara
Lars Stumpp
Richard Reilly
Omar Mamad

Subjects

Architecture

Topics
ca1 region hippocampal physiology dopaminergic neurons place animals spatial memory assembly maze learning male ventral tegmental area rats

Place field assembly distribution encodes preferred locations (2017)

Abstract The hippocampus is the main locus of episodic memory formation and the neurons there encode the spatial map of the environment. Hippocampal place cells represent location, but their role in the learning of preferential location remains unclear. The hippocampus may encode locations independently from the stimuli and events that are associated with these locations. We have discovered a unique population code for the experience-dependent value of the context. The degree of reward-driven navigation preference highly correlates with the spatial distribution of the place fields recorded in the CA1 region of the hippocampus. We show place field clustering towards rewarded locations. Optogenetic manipulation of the ventral tegmental area demonstrates that the experience-dependent place field assembly distribution is directed by tegmental dopaminergic activity. The ability of the place cells to remap parallels the acquisition of reward context. Our findings present key evidence that the hippocampal neurons are not merely mapping the static environment but also store the concurrent context reward value, enabling episodic memory for past experience to support future adaptive behavior.
Collections Ireland -> Trinity College Dublin -> Administrative Staff Authors (Scholarly Publications)
Ireland -> Trinity College Dublin -> Administrative Staff Authors

Full list of authors on original publication

Marian Tsanov, Karl Deisseroth, Charu Ramakrishnan, Harold M McNamara, Lars Stumpp, Richard Reilly, Omar Mamad

Experts in our system

1
Marian Tsanov
Trinity College Dublin
Total Publications: 11
 
2
Richard Reilly
Trinity College Dublin
Total Publications: 183