Type

Journal Article

Authors

Michael Hutchinson
Seán O'Riordan
Owen Killian
Rebecca Beck
Shruti Narasimham
Eavan M McGovern
Richard Reilly
Antonella Conte

Subjects

Psychology

Topics
adult dystonia relevance environmental factors temporal discrimination basal ganglia diseases inter rater reliability somatosensory cortex

Temporal discrimination: Mechanisms and relevance to adult-onset dystonia (2017)

Abstract Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as being asynchronous; this can be assessed, with high test-retest and inter-rater reliability, using a simple psychophysical test. Temporal discrimination is disordered in a number of basal ganglia diseases including adult-onset dystonia, of which the two most common phenotypes are cervical dystonia and blepharospasm. The causes of adult-onset focal dystonia are unknown; genetic, epigenetic, and environmental factors are relevant. Abnormal TDTs in adult-onset dystonia are associated with structural and neurophysiological changes considered to reflect defective inhibitory interneuronal processing within a network which includes the superior colliculus, basal ganglia, and primary somatosensory cortex. It is hypothesized that abnormal temporal discrimination is a mediational endophenotype and, when present in unaffected relatives of patients with adult-onset dystonia, indicates non-manifesting gene carriage. Using the mediational endophenotype concept, etiological factors in adult-onset dystonia may be examined including (i) the role of environmental exposures in disease penetrance and expression; (ii) sexual dimorphism in sex ratios at age of onset; (iii) the pathogenesis of non-motor symptoms of adult-onset dystonia; and (iv) subcortical mechanisms in disease pathogenesis.
Collections Ireland -> Trinity College Dublin -> Administrative Staff Authors (Scholarly Publications)
Ireland -> Trinity College Dublin -> Administrative Staff Authors

Full list of authors on original publication

Michael Hutchinson, Seán O'Riordan, Owen Killian, Rebecca Beck, Shruti Narasimham, Eavan M McGovern, Richard Reilly, Antonella Conte

Experts in our system

1
Michael Hutchinson
University College Dublin
Total Publications: 79
 
2
Sean O'Riordan
Trinity College Dublin
Total Publications: 20
 
3
Rebecca Beck
University College Dublin
Total Publications: 9
 
4
Shruti Narasimham
Trinity College Dublin
Total Publications: 5
 
5
Eavan McGovern
Trinity College Dublin
Total Publications: 14
 
6
Richard Reilly
Trinity College Dublin
Total Publications: 183