Type

Journal Article

Authors

Cathal J Kearney
Fergal O'Brien
Henrique V Almeida
Daniel Kelly
Ronaldo J F C do Amaral

Subjects

Biology

Topics
this review stem cells stem cell biology infrapatellar fat pad developmental biology synovial membrane adipose derived stem cells cell therapy

Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy (2017)

Abstract The ideal cell type to be used for cartilage therapy should possess a proven chondrogenic capacity, not cause donor-site morbidity, and should be readily expandable in culture without losing their phenotype. There are several cell sources being investigated to promote cartilage regeneration: mature articular chondrocytes, chondrocyte progenitors, and various stem cells. Most recently, stem cells isolated from joint tissue, such as chondrogenic stem/progenitors from cartilage itself, synovial fluid, synovial membrane, and infrapatellar fat pad (IFP) have gained great attention due to their increased chondrogenic capacity over the bone marrow and subcutaneous adipose-derived stem cells. In this review, we first describe the IFP anatomy and compare and contrast it with other adipose tissues, with a particular focus on the embryological and developmental aspects of the tissue. We then discuss the recent advances in IFP stem cells for regenerative medicine. We compare their properties with other stem cell types and discuss an ontogeny relationship with other joint cells and their role on
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Full list of authors on original publication

Cathal J Kearney, Fergal O'Brien, Henrique V Almeida, Daniel Kelly, Ronaldo J F C do Amaral

Experts in our system

1
Cathal J Kearney
Royal College of Surgeons in Ireland
Total Publications: 14
 
2
Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 265
 
3
Henrique V Almeida
Royal College of Surgeons in Ireland
Total Publications: 8
 
4
Daniel L Kelly
Trinity College Dublin
Total Publications: 21