Type

Journal Article

Authors

Derek W Morris
Aiden Corvin
Michael C O'Donovan
Michael Owen
Kiran Mantripragada
Alex Richards
Tracy Petryshen
Gabriella Blokland
Nicholas J. Bray
Matthew J. Hill
and 6 others

Subjects

Psychiatry

Topics
cognitive cognitive psychology patients schizophrenia genome wide association cognitive functions spatial working memory controls mir psychology polygenic

MiR-137-derived polygenic risk: Effects on cognitive performance in patients with schizophrenia and controls (2017)

Abstract Variants at microRNA-137 (MIR137), one of the most strongly associated schizophrenia risk loci identified to date, have been associated with poorer cognitive performance. As microRNA-137 is known to regulate the expression of ~1900 other genes, including several that are independently associated with schizophrenia, we tested whether this gene set was also associated with variation in cognitive performance. Our analysis was based on an empirically derived list of genes whose expression was altered by manipulation of MIR137 expression. This list was cross-referenced with genome-wide schizophrenia association data to construct individual polygenic scores. We then tested, in a sample of 808 patients and 192 controls, whether these risk scores were associated with altered performance on cognitive functions known to be affected in schizophrenia. A subgroup of healthy participants also underwent functional imaging during memory (n=108) and face processing tasks (n=83). Increased polygenic risk within the empirically derived miR-137 regulated gene score was associated with significantly lower performance on intelligence quotient, working memory and episodic memory. These effects were observed most clearly at a polygenic threshold of P=0.05, although significant results were observed at all three thresholds analyzed. This association was found independently for the gene set as a whole, excluding the schizophrenia-associated MIR137 SNP itself. Analysis of the spatial working memory fMRI task further suggested that increased risk score (thresholded at P=10−5) was significantly associated with increased activation of the right inferior occipital gyrus. In conclusion, these data are consistent with emerging evidence that MIR137 associated risk for schizophrenia may relate to its broader downstream genetic effects.
Collections Ireland -> National College Ireland -> Status = Published
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognitive psychology
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Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> Trinity College Dublin -> Psychiatry
Ireland -> Trinity College Dublin -> School of Medicine
Ireland -> Trinity College Dublin -> Psychiatry (Scholarly Publications)
Ireland -> National College Ireland -> Type = Article
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Full list of authors on original publication

Derek W Morris, Aiden Corvin, Michael C O'Donovan, Michael Owen, Kiran Mantripragada, Alex Richards, Tracy Petryshen, Gabriella Blokland, Nicholas J. Bray, Matthew J. Hill and 6 others

Experts in our system

1
Derek Morris
Trinity College Dublin
Total Publications: 168
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 218
 
3
Michael C O'Donovan
Trinity College Dublin
Total Publications: 23
 
4
Michael J. Owen
Trinity College Dublin
Total Publications: 24
 
5
Kiran Mantripragada
National College Ireland
Total Publications: 7
 
6
Alex Richards
Dublin City University
Total Publications: 9