Type

Journal Article

Authors

Dermot P Kelleher
Deirdre Duff
Aoife Maguire
John Reynolds
Osama Sharaf Eldin
Anne-Marie Byrne
Brendan Doyle
Aideen Long
Ronan Feighery
Jacintha O'Sullivan
and 3 others

Subjects

Chemistry

Topics
v v cancer trafficking bile acids cell line deoxycholic acid genes society gastroesophageal reflux extracellular matrix cell adhesion cell models

Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-??v trafficking (2017)

Abstract The fundamental mechanisms underlying erosive oesophagitis and subsequent development of Barrett's oesophagus (BO) are poorly understood. Here, we investigated the contribution of specific components of the gastric refluxate on adhesion molecules involved in epithelial barrier maintenance. Cell line models of squamous epithelium (HET-1A) and BO (QH) were used to examine the effects of bile acids on cell adhesion to extracellular matrix proteins (Collagen, laminin, vitronectin, fibronectin) and expression of integrin ligands (α
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Full list of authors on original publication

Dermot P Kelleher, Deirdre Duff, Aoife Maguire, John Reynolds, Osama Sharaf Eldin, Anne-Marie Byrne, Brendan Doyle, Aideen Long, Ronan Feighery, Jacintha O'Sullivan and 3 others

Experts in our system

1
Dermot Kelleher
Trinity College Dublin
Total Publications: 149
 
2
Deirdre Duff
Trinity College Dublin
Total Publications: 3
 
3
Aoife Maguire
Trinity College Dublin
Total Publications: 5
 
4
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
5
Anne-Marie Byrne
Trinity College Dublin
Total Publications: 8
 
6
Brendan Doyle
Trinity College Dublin
Total Publications: 16
 
7
Aideen Long
Trinity College Dublin
Total Publications: 71
 
8
Ronan Feighery
Trinity College Dublin
Total Publications: 10
 
9
Jacintha O'Sullivan
Trinity College Dublin
Total Publications: 74