Type

Journal Article

Authors

Gary Donohoe
Derek W Morris
Aiden Corvin
Michael Gill
Michael C O'Donovan
Michael Owen
Kiran Mantripragada
Alex Richards
Richard Anney
Jessica Holland
and 6 others

Subjects

Psychiatry

Topics
schizophrenia genetic genome wide association studies patients surface area brain risk measures memory function

Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls. (2017)

Abstract Multiple genome-wide association studies of schizophrenia have implicated genetic variants within the gene encoding microRNA-137. As risk variants within or regulated by MIR137 have been implicated in memory performance, we investigated the additive effects of schizophrenia-associated risk variants in genes empirically regulated by MIR137 on brain regions associated with memory function. A polygenic risk score (PRS) was calculated (at a p = 0.05 threshold), using this empirically regulated MIR137 gene set, to investigate associations between this PRS and structural brain measures. These measures included total brain volume, cortical thickness, cortical surface area, and hippocampal volume, in a sample of 216 individuals consisting of healthy participants (n = 171) and patients with psychosis (n = 45). We did not observe a significant association between MIR137 PRS and these cortical thickness, surface area or hippocampal volume measures linked to memory function; a significant association between increasing PRS and decreasing total brain volume, independent of diagnosis status (R
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Gary Donohoe, Derek W Morris, Aiden Corvin, Michael Gill, Michael C O'Donovan, Michael Owen, Kiran Mantripragada, Alex Richards, Richard Anney, Jessica Holland and 6 others

Experts in our system

1
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
2
Derek Morris
Trinity College Dublin
Total Publications: 150
 
3
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
4
Michael Gill
Trinity College Dublin
Total Publications: 260
 
5
M C O'Donovan
Trinity College Dublin
Total Publications: 18
 
6
Michael J Owen
Royal College of Surgeons in Ireland
Total Publications: 19
 
7
Kiran Mantripragada
Dublin City University
Total Publications: 5
 
8
Alex Richards
Dublin City University
Total Publications: 6
 
9
Richard Anney
Trinity College Dublin
Total Publications: 38