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Type

Journal Article

Authors

John Crown
Norma O'Donovan
Alex J Eustace
Naomi Walsh
Neil A O'Brien
Denis M Collins
Neil T. Conlon
Zulfiqar Qadir
Alexandra Canonici

Subjects

Biochemistry

Topics
cancer cells trastuzumab breast cancer cancer cell lines cell models molecular chaperone inhibitor her2 positive

The HSP90 inhibitor NVP-AUY922 inhibits growth of HER2 positive and trastuzumab-resistant breast cancer cells. (2017)

Abstract As HER2 is a client protein of the molecular chaperone Hsp90, targeting Hsp90 may be beneficial in HER2-positive breast cancer. In this study, the activity of the Hsp90 inhibitor NVP-AUY922 was assessed in HER2 overexpressing breast cancer cell lines, including two cell line models of acquired trastuzumab-resistance. The seven HER2-positive breast cancer cell lines tested showed significant sensitivity to NVP-AUY922 in vitro, with IC
Url http://www.ncbi.nlm.nih.gov/pubmed/29396630
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

John Crown, Norma O'Donovan, Alex J Eustace, Naomi Walsh, Neil A O'Brien, Denis M Collins, Neil T. Conlon, Zulfiqar Qadir, Alexandra Canonici

Experts in our system

1
John Crown
Dublin City University
Biochemistry Medicine & Nursing Microbiology
Total Publications: 104
 
2
Norma O'Donovan
Dublin City University
Biochemistry Pharmacology
Total Publications: 59
 
3
Alex J Eustace
Dublin City University
Biochemistry Medicine & Nursing Microbiology
Total Publications: 27
 
4
Naomi Walsh
Dublin City University
Biochemistry
Total Publications: 22
 
5
Neil A O'Brien
Dublin City University
Biochemistry Microbiology Pharmacology
Total Publications: 9
 
6
Denis M Collins
Dublin City University
Microbiology Biochemistry Pharmacology
Total Publications: 26
 
7
Neil T. Conlon
Dublin City University
Biochemistry Medicine & Nursing
Total Publications: 10
 
8
Alexandra Canonici
Dublin City University
Medicine & Nursing Biochemistry Pharmacology
Total Publications: 5