Type

Journal Article

Authors

Michael D Gilchrist
Jeremiah G Murphy
Baptiste Pierrat
David B MacManus

Subjects

Physiotherapy & Sport

Topics
brain injuries young adult viscoelastic properties young adults brain tissue computational models mechanical properties strain rates

Region and species dependent mechanical properties of adolescent and young adult brain tissue. (2017)

Abstract Traumatic brain injuries, the leading cause of death and disability in children and young adults, are the result of a rapid acceleration or impact of the head. In recent years, a global effort to better understand the biomechanics of TBI has been undertaken, with many laboratories creating detailed computational models of the head and brain. For these models to produce realistic results they require accurate regional constitutive data for brain tissue. However, there are large differences in the mechanical properties reported in the literature. These differences are likely due to experimental parameters such as specimen age, brain region, species, test protocols, and fiber direction which are often not reported. Furthermore, there is a dearth of reported viscoelastic properties for brain tissue at large-strain and high rates. Mouse, rat, and pig brains are impacted at 10/s to a strain of ~36% using a custom-built micro-indenter with a 125 μm radius. It is shown that the resultant mechanical properties are dependent on specimen-age, species, and region, under identical experimental parameters.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Michael D Gilchrist, Jeremiah G Murphy, Baptiste Pierrat, David B MacManus

Experts in our system

1
M. D. Gilchrist
University College Dublin
Total Publications: 172
 
2
Jeremiah G Murphy
Dublin City University
Total Publications: 16
 
3
Baptiste Pierrat
Dublin City University
Total Publications: 8
 
4
David B MacManus
Dublin City University
Total Publications: 9