Type

Journal Article

Authors

Michael F Gallagher
John J O'Leary
Sharon O'Toole
Helen Lambkin
Ciaran O'Riain
Britta Stordal
Bryan T Hennessy
Noreen Gleeson
Dearbhaile O'Donnell
Brendan Doyle
and 10 others

Subjects

Biochemistry

Topics
single cell ovarian cancer resistance biology aldehyde dehydrogenase validation component cancer stem cells

CD10 (2017)

Abstract It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CSC hierarchies and chemoresistance in an ovarian cancer model. Using a single cell-based approach to CSC discovery and validation, we report a novel, four-component CSC hierarchy based around the markers cluster of differentiation 10 (CD10) and aldehyde dehydrogenase (ALDH). In a change to our understanding of CSC biology, resistance to chemotherapy drug cisplatin was found to be the sole property of CD10
Collections Ireland -> Dublin Institute of Technology -> PubMed

Full list of authors on original publication

Michael F Gallagher, John J O'Leary, Sharon O'Toole, Helen Lambkin, Ciaran O'Riain, Britta Stordal, Bryan T Hennessy, Noreen Gleeson, Dearbhaile O'Donnell, Brendan Doyle and 10 others

Experts in our system

1
Michael Gallagher
Trinity College Dublin
Total Publications: 21
 
2
John O'Leary
Trinity College Dublin
Total Publications: 93
 
3
Sharon O'Toole
Trinity College Dublin
Total Publications: 29
 
4
Helen Lambkin
Dublin Institute of Technology
Total Publications: 23
 
5
Britta Kristina Stordal
Trinity College Dublin
Total Publications: 29
 
6
Bryan T Hennessy
Royal College of Surgeons in Ireland
Total Publications: 33
 
7
Noreen Gleeson
Trinity College Dublin
Total Publications: 10
 
8
Dearbhaile O'Donnell
Trinity College Dublin
 
9
Brendan Doyle
Trinity College Dublin
Total Publications: 16