Type

Journal Article

Authors

Markus Rehm
Thomas Brunner
Ana J García-Sáez
Kushal K Das
Annika Hantusch

Subjects

Biochemistry

Topics
sensitivity family members membrane cell death primary mitochondrial species bcl 2 family

Bax retrotranslocation potentiates Bcl-x (2017)

Abstract The rapid, typically all-or-none process of mitochondrial outer membrane permeabilization (MOMP) constitutes a primary cell death decision that is controlled by the Bcl-2 family interactome. However, how strict all-or-none MOMP decisions are governed by and emanate from the dynamic interplay of pro- and antiapoptotic Bcl-2 family members remains incompletely understood. In particular, it is unclear to which extent the shuttling of Bcl-2 family species between lipid and aqueous phases contributes to regulating MOMP sensitivity. Here, we studied the interplay of tBid, Bax, and Bcl-x
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Markus Rehm, Thomas Brunner, Ana J García-Sáez, Kushal K Das, Annika Hantusch

Experts in our system

1
Markus Rehm
Royal College of Surgeons in Ireland
Total Publications: 55