Type

Journal Article

Authors

Seamus J Martin
Ed C Lavelle
Noel G McElvaney
Emer P Reeves
Conor M Henry
Hannah B T Moran
Graeme P Sullivan
Danielle M Clancy

Subjects

Microbiology

Topics
il 1 neutrophil anti microbial proteases inflammatory reactions cytokine il 1 extracellular space microbial

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing. (2016)

Abstract Neutrophil granule proteases are thought to function as anti-microbial effectors, cooperatively hydrolyzing microorganisms within phagosomes, or upon deployment into the extracellular space. However, evidence also suggests that neutrophil proteases play an important role in the coordination and escalation of inflammatory reactions, but how this is achieved has been obscure. IL-1 family cytokines are important initiators of inflammation and are typically released via necrosis but require proteolytic processing for activation. Here, we show that proteases liberated from activated neutrophils can positively or negatively regulate the activity of six IL-1 family cytokines (IL-1α, IL-1β, IL-33, IL-36α, IL-36β, and IL-36γ) with exquisite sensitivity. In contrast, extracellular neutrophil proteases displayed very poor bactericidal activity, exhibiting 100-fold greater potency toward cytokine processing than bacterial killing. Thus, in addition to their classical role as phagocytes, neutrophils play an important immunoregulatory role through deployment of their granule proteases into the extracellular space to process multiple IL-1 family cytokines.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Seamus J Martin, Ed C Lavelle, Noel G McElvaney, Emer P Reeves, Conor M Henry, Hannah B T Moran, Graeme P Sullivan, Danielle M Clancy

Experts in our system

1
Seamus Martin
Trinity College Dublin
Total Publications: 46
 
2
Ed C Lavelle
Trinity College Dublin
Total Publications: 31
 
3
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
4
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63
 
5
Hannah B T Moran
Trinity College Dublin
Total Publications: 4
 
6
Danielle M Clancy
Trinity College Dublin
Total Publications: 3