Type

Journal Article

Authors

Graham M Lord
Michael E Weale
Nicole Soranzo
Gerhard Opelz
Peter Conlon
Steven H Sacks
Robert Vaughan
Peter Topham
Richard Trembath
Raj Thuraisingham
and 35 others

Subjects

Medicine & Nursing

Topics
genome wide association study immune response large scale united kingdom genetic variation european union renal transplant patient data

Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study. (2017)

Abstract Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied deceased-donor grafts allocated on the basis of preferential HLA matching, which provided some control for HLA genetic effects. No strong donor or recipient genetic effects contributing to long- or short-term allograft survival were found outside the HLA region. We discuss the implications for future research and clinical application.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Graham M Lord, Michael E Weale, Nicole Soranzo, Gerhard Opelz, Peter Conlon, Steven H Sacks, Robert Vaughan, Peter Topham, Richard Trembath, Raj Thuraisingham and 35 others

Experts in our system

1
Peter J Conlon
Royal College of Surgeons in Ireland
Total Publications: 16