Type

Journal Article

Authors

Jochen H M Prehn
Elaine W Kay
Deborah McNamara
Markus Rehm
Joanna Fay
Orna Bacon
Manuela Salvucci
Naser Monsefi
Beatrice D'Orsi
Steven Carberry

Subjects

Medicine & Nursing

Topics
caspase 3 prognostic cancer patients cancer chemotherapy er stress protein bcl 2 family colorectal cancer

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. (2017)

Abstract The intrinsic or mitochondrial apoptosis pathway is controlled by the interaction of antiapoptotic and pro-apoptotic members of the BCL-2 protein family. Activation of this death pathway plays a crucial role in cancer progression and chemotherapy responses. The BCL-2-related ovarian killer (BOK) possesses three BCL-2 homology domains and has been proposed to act in a similar pro-apoptotic pathway as the pro-apoptotic proteins BAX and BAK. In this study, we showed that stage II and III colorectal cancer patients possessed decreased levels of BOK protein in their tumours compared to matched normal tissue. BOK protein levels in tumours were also prognostic of clinical outcome but increased BOK protein levels surprisingly associated with earlier disease recurrence and reduced overall survival. We found no significant association of BOK protein tumour levels with ER stress markers GRP78 or GRP94 or with cleaved caspase-3. In contrast, BOK protein levels correlated with Calreticulin. These data indicate BOK as a prognostic marker in colorectal cancer and suggest that different activities of BOK may contribute to cancer progression and prognosis.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Jochen H M Prehn, Elaine W Kay, Deborah McNamara, Markus Rehm, Joanna Fay, Orna Bacon, Manuela Salvucci, Naser Monsefi, Beatrice D'Orsi, Steven Carberry

Experts in our system

1
Jochen H M Prehn
Royal College of Surgeons in Ireland
Total Publications: 206
 
2
Elaine W Kay
Royal College of Surgeons in Ireland
Total Publications: 157
 
3
Deborah A McNamara
Royal College of Surgeons in Ireland
Total Publications: 17
 
4
Markus Rehm
Royal College of Surgeons in Ireland
Total Publications: 55
 
5
Joanna Fay
Royal College of Surgeons in Ireland
Total Publications: 24
 
6
Orna Bacon
Royal College of Surgeons in Ireland
Total Publications: 13
 
7
Manuela Salvucci
Royal College of Surgeons in Ireland
 
8
Beatrice D'Orsi
Royal College of Surgeons in Ireland
Total Publications: 14
 
9
Steven Carberry
Royal College of Surgeons in Ireland
Total Publications: 4