Journal Article


Guido Kroemer
Gerry Melino
Laurence Zitvogel
Boris Zhivotovsky
Zahra Zakeri
Junying Yuan
Will Wood
James A Wells
Ying Wang
David Wallach
and 159 others



nomenclature mitotic catastrophe apoptosis cell death classification recommendations support molecular

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. (2017)

Abstract Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Guido Kroemer, Gerry Melino, Laurence Zitvogel, Boris Zhivotovsky, Zahra Zakeri, Junying Yuan, Will Wood, James A Wells, Ying Wang, David Wallach and 159 others

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