Type

Journal Article

Authors

Catherine M Greene
Sally-Ann Cryan
Ronan MacLoughlin
Joanne M Ramsey
Chiara De Santi
Beatriz Santos-Carballal
Elena Fernández Fernández

Subjects

Microbiology

Topics
cystic fibrosis lung nucleic acids disease non viral nanoparticles epithelial cells gene therapy

Biopolymer-Based Nanoparticles for Cystic Fibrosis Lung Gene Therapy Studies. (2017)

Abstract Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore, optimal delivery of emerging therapeutics to airway epithelial cells demands suitable non-viral systems. In this work, we describe the formulation and the physicochemical investigation of biocompatible and biodegradable polymeric nanoparticles (NPs), including PLGA and chitosan (animal and non-animal), as novel methods for the safe and efficient delivery of CFTR-specific locked nucleic acids (LNAs).
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Catherine M Greene, Sally-Ann Cryan, Ronan MacLoughlin, Joanne M Ramsey, Chiara De Santi, Beatriz Santos-Carballal, Elena Fernández Fernández

Experts in our system

1
Catherine M Greene
Royal College of Surgeons in Ireland
Total Publications: 150
 
2
Sally-Ann Cryan
Royal College of Surgeons in Ireland
Total Publications: 70
 
3
Ronan MacLoughlin
University College Cork
Total Publications: 3
 
4
Joanne M Ramsey
Royal College of Surgeons in Ireland
Total Publications: 5
 
5
Chiara De Santi
Royal College of Surgeons in Ireland
Total Publications: 5