Type

Journal Article

Authors

Fergal J O'Brien
Daniel J Kelly
John P Gleeson
Tatiana Vinardell
Gráinne M Cunniffe
Cai Lloyd-Griffith
Emmet M Thompson
Amos Matsiko

Subjects

Biochemistry

Topics
endochondral ossification bone mesenchymal stem cells collagen scaffolds cartilage repair cartilage tissue weight bearing tissue engineering

An endochondral ossification approach to early stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair. (2017)

Abstract Mimicking endochondral ossification to engineer constructs offers a novel solution to overcoming the problems associated with poor vascularisation in bone repair. This can be achieved by harnessing the angiogenic potency of hypertrophic cartilage. In this study, we demonstrate that tissue-engineered hypertrophically primed cartilage constructs can be developed from collagen-based scaffolds cultured with mesenchymal stem cells. These constructs were subsequently implanted into femoral defects in rats. It was evident that the constructs could support enhanced early stage healing at 4 weeks of these weight-bearing femoral bone defects compared to untreated defects. This study demonstrates the value of combining knowledge of development biology and tissue engineering in a developmental engineering inspired approach to tissue repair.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Fergal J O'Brien, Daniel J Kelly, John P Gleeson, Tatiana Vinardell, Gráinne M Cunniffe, Cai Lloyd-Griffith, Emmet M Thompson, Amos Matsiko

Experts in our system

1
Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 268
 
2
Daniel Kelly
Trinity College Dublin
Total Publications: 190
 
3
John P Gleeson
Royal College of Surgeons in Ireland
Total Publications: 26
 
4
Tatiana Vinardell
Trinity College Dublin
Total Publications: 27
 
5
Grainne M Cunniffe
Royal College of Surgeons in Ireland
Total Publications: 16
 
6
Cai Lloyd-Griffith
Royal College of Surgeons in Ireland
Total Publications: 3
 
7
Emmet M Thompson
Royal College of Surgeons in Ireland
Total Publications: 17
 
8
Amos Matsiko
Royal College of Surgeons in Ireland
Total Publications: 24