Type

Journal Article

Authors

Patrick G Morris
Bryan T Hennessy
Jack P Gleeson
Niamh M Keegan

Subjects

Biochemistry

Topics
phosphatidylinositol 3 kinase drug resistance neoplasm breast neoplasms pik3ca protein human antagonists inhibitors humans pathology receptors estrogen drug design pharmacology antineoplastic agents enzymology drug therapy receptor erbb 2 female erbb2 protein human class i phosphatidylinositol 3 kinases biomarkers tumor genetics metabolism

PI3K inhibition to overcome endocrine resistance in breast cancer. (2017)

Abstract Activation of the phosphatidylinositol-3 kinase (PI3K) pathway is a critical step in oncogenesis and plays a role in the development of treatment resistance for both estrogen receptor (ER) positive and human epidermal growth factor receptor 2 (HER2) positive breast cancers. Hence, there have been efforts to therapeutically inhibit this pathway. Areas covered: Several inhibitors of PI3K are now progressing through clinical trials with varying degrees of efficacy and toxicity to date. Numerous unresolved questions remain concerning the optimal isoform selectivity of PI3K inhibitors and use of predictive biomarkers. This review examines the most important PI3K inhibitors in ER positive breast cancer to date, with a particular focus on their role in overcoming endocrine therapy resistance and the possible use of PIK3CA mutations as a predictive biomarker. Expert opinion: We discuss some of the emerging challenges and questions encountered during the development of PI3K inhibitors from preclinical to phase III studies, including other novel biomarkers and future combinations to overcome endocrine resistance.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Patrick G Morris, Bryan T Hennessy, Jack P Gleeson, Niamh M Keegan

Experts in our system

1
Bryan T Hennessy
Royal College of Surgeons in Ireland
Total Publications: 33