Journal Article


Peter J MacMahon
Eoin C Kavanagh
Sean Murphy
Peter Kelly
Cathal D. Walsh
Michael Marnane
Emma Stanley
Gavin Sugrue
John P Walsh
Danielle Byrne



ethics processing angiography processes patients acute ischaemic stroke detection subtraction technique

Subtraction multiphase CT angiography: A new technique for faster detection of intracranial arterial occlusions. (2017)

Abstract To describe and evaluate a novel technical development to improve detection of intracranial vessel occlusions using multiphase CT angiography (MPCTA). The institutional ethics committee approved the study. Fifty patients (30 consecutive distal (M2 or smaller) anterior circulation occlusions, ten M1 occlusions, ten cases without occlusion) presenting with suspected AIS who underwent MPCTA were included. Post-processing of MPCTA studies created "subtraction" and "delayed enhancement" (DE) datasets. Initially, non-contrast CT and MPCTA studies for each patient were evaluated. Readers' confidence, speed and sensitivity of detection of intracranial vessel occlusions were recorded. After an interval of at least 4 weeks, readers were provided with post-processed images and studies were re-evaluated. While the sensitivity of detection of intracranial vessel occlusions was equal for both conventional MPCTA and subMPCTA, the mean time taken to identify a vessel occlusion decreased by 64 % using subMPCTA (16 s vs. 45 s with conventional MPCTA) (p<0.001). In addition, confidence in interpretation improved (from 4.4 to 4.9) using subMPCTA (p<0.001). SubMPCTA is a novel technique that aids in identifying small intracranial vessel occlusions in the suspected AIS patient. SubMPCTA increases confidence in interpretation and reduces the time taken to detect intracranial vessel occlusions. • SubMPCTA processes MPCTA data to better demonstrate intracranial arterial occlusions. • SubMPCTA increases confidence and speed of interpretation of MPCTA studies. • SubMPCTA may aid in rapidly differentiating acute ischaemic stroke from stroke mimics.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Peter J MacMahon, Eoin C Kavanagh, Sean Murphy, Peter Kelly, Cathal D. Walsh, Michael Marnane, Emma Stanley, Gavin Sugrue, John P Walsh, Danielle Byrne

Experts in our system

Eoin Kavanagh
University College Dublin
Total Publications: 17
Sean Murphy
University College Dublin
Total Publications: 39
Peter J Kelly
University College Dublin
Total Publications: 48
Cathal Walsh
University of Limerick
Total Publications: 109
Michael Marnane
University College Dublin
Total Publications: 15