Type

Journal Article

Authors

Linda Giblin
Paul L H McSweeney
Alan L Kelly
John F Cryan
Brian Murray
Harriët Schellekens
Brian McGrath
Christine Bruen
Fiona O'Halloran

Subjects

Veterinary

Topics
cell line casein mice increases bioactive peptides food intake weight gain secretion

A casein hydrolysate increases GLP-1 secretion and reduces food intake. (2017)

Abstract In an effort to control weight gain, much attention has focused on the identification of bioactive peptides from food sources that induce satiety hormone secretion and increase the feeling of fullness. In this study, a screening platform identified a sodium caseinate hydrolysate, LFC25, that significantly increased calcium signalling in the enteroendocrine cell line, STC-1, and as a result increased secretion of the satiety hormone, GLP-1, in a dose-dependent manner. Administration of this hydrolysate to mice reduced the cumulative food intake over an eight hour period. To determine the feasibility of LFC25 as a food ingredient, production was scaled up to 10 L and spray-dried or freeze-dried without loss of bioactivity.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

Linda Giblin, Paul L H McSweeney, Alan L Kelly, John F Cryan, Brian Murray, Harriët Schellekens, Brian McGrath, Christine Bruen, Fiona O'Halloran

Experts in our system

1
Linda Giblin
Teagasc
Total Publications: 45
 
 
3
Alan L. Kelly
Teagasc
Total Publications: 63
 
4
Brian A. Murray
Teagasc
Total Publications: 19
 
5
Harriët Schellekens
University College Cork
Total Publications: 29
 
6
Christine M Bruen
Teagasc
Total Publications: 6
 
7
Fiona O'Halloran
Teagasc
Total Publications: 9