Journal Article


P D Cotter
C Hill
R P Ross
C M Guinane
J W Hegarty



production lactobacillus acidophilus bacterial strains gene expression heterogeneity bacteriocin gastrointestinal tract commercial products

Lack of Heterogeneity in Bacteriocin Production Across a Selection of Commercial Probiotic Products. (2017)

Abstract Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit to the host. Bacteriocin production has often been mooted as a desirable probiotic trait and, in specific cases, has been shown to promote probiotic survival within the gastrointestinal tract, contribute to the control of pathogens and even influence host gene expression in the gut. However, it is not clear what proportion of probiotic strains routinely found in commercial products produces bacteriocins, and additionally, it is not known which bacteriocins are produced most frequently. To address this, we conducted a culture-based assessment of the bacteriocinogenic ability of bacterial strains found in a variety of commercially available probiotic products. We detected eight bacteriocin-producing isolates from 16 tested products. Interestingly, in all cases, the isolates were Lactobacillus acidophilus, and the bacteriocin produced was identified as the narrow spectrum class II bacteriocin, lactacin B. The apparent absence of other bacteriocin-producing strains from across these products suggests a lack of heterogeneity in bacteriocin production within probiotic products and suggests that bacteriocin production is not being optimally harnessed as a probiotic trait.
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Full list of authors on original publication

P D Cotter, C Hill, R P Ross, C M Guinane, J W Hegarty

Experts in our system

Paul D. Cotter
Total Publications: 253
Colin Hill
University College Cork
Total Publications: 351
R Paul Ross
Total Publications: 441
Caitriona M Guinane
Total Publications: 35