Type

Journal Article

Authors

Jacintha O'Sullivan
David Fennelly
Hugh Mulcahy
Diarmuid O'Donoghue
Kieran Sheahan
John Hyland
Bláthnaid Nolan
Miriam Tosetto
Aoife Maguire
Shane O'Meachair
and 4 others

Subjects

Medicine & Nursing

Topics
cancer treatment oxidative dna damage cancer patients systemic inflammation tumour vasculature cancer survival colorectal cancer inflammatory cytokines

Tumour vasculature immaturity, oxidative damage and systemic inflammation stratify survival of colorectal cancer patients on bevacizumab treatment. (2017)

Abstract Despite treatment of patients with metastatic colorectal cancer (mCRC) with bevacizumab plus chemotherapy, response rates are modest and there are no biomarkers available that will predict response. The aim of this study was to assess if markers associated with three interconnected cancer-associated biological processes, specifically angiogenesis, inflammation and oxidative damage, could stratify the survival outcome of this cohort. Levels of angiogenesis, inflammation and oxidative damage markers were assessed in pre-bevacizumab resected tumour and serum samples of mCRC patients by dual immunofluorescence, immunohistochemistry and ELISA. This study identified that specific markers of angiogenesis, inflammation and oxidative damage stratify survival of patients on this anti-angiogenic treatment. Biomarkers of immature tumour vasculature (% IMM, p=0.026, n=80), high levels of oxidative damage in the tumour epithelium (intensity of 8-oxo-dG in nuclear and cytoplasmic compartments, p=0.042 and 0.038 respectively, n=75) and lower systemic pro-inflammatory cytokines (IL6 and IL8, p=0.053 and 0.049 respectively, n=61) significantly stratify with median overall survival (OS). In summary, screening for a panel of biomarkers for high levels of immature tumour vasculature, high levels of oxidative DNA damage and low levels of systemic pro-inflammatory cytokines may be beneficial in predicting enhanced survival outcome following bevacizumab treatment for mCRC.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Jacintha O'Sullivan, David Fennelly, Hugh Mulcahy, Diarmuid O'Donoghue, Kieran Sheahan, John Hyland, Bláthnaid Nolan, Miriam Tosetto, Aoife Maguire, Shane O'Meachair and 4 others

Experts in our system

1
Jacintha O'Sullivan
Trinity College Dublin
Total Publications: 74
 
2
David Fennelly
Trinity College Dublin
Total Publications: 11
 
3
Hugh E Mulcahy
University College Dublin
Total Publications: 43
 
4
Diarmuid O'Donoghue
University College Dublin
Total Publications: 42
 
5
Kieran Sheahan
University College Dublin
Total Publications: 40
 
6
John Hyland
Dublin Business School
Total Publications: 47
 
7
Blathnaid Nolan
Trinity College Dublin
Total Publications: 8
 
8
Miriam Tosetto
Trinity College Dublin
Total Publications: 15
 
9
Aoife Maguire
Trinity College Dublin
Total Publications: 5