Type

Journal Article

Authors

Russell L McLaughlin
Daniel G Bradley
Orla Hardiman
Garrett Hellenthal
Matthew Carrigan
Lara M Cassidy
Rui Martiniano
Ross P Byrne

Subjects

Biology

Topics
communication y chromosome genomic migration ireland genetic variation population structure irish genome

Insular Celtic population structure and genomic footprints of migration. (2017)

Abstract Previous studies of the genetic landscape of Ireland have suggested homogeneity, with population substructure undetectable using single-marker methods. Here we have harnessed the haplotype-based method fineSTRUCTURE in an Irish genome-wide SNP dataset, identifying 23 discrete genetic clusters which segregate with geographical provenance. Cluster diversity is pronounced in the west of Ireland but reduced in the east where older structure has been eroded by historical migrations. Accordingly, when populations from the neighbouring island of Britain are included, a west-east cline of Celtic-British ancestry is revealed along with a particularly striking correlation between haplotypes and geography across both islands. A strong relationship is revealed between subsets of Northern Irish and Scottish populations, where discordant genetic and geographic affinities reflect major migrations in recent centuries. Additionally, Irish genetic proximity of all Scottish samples likely reflects older strata of communication across the narrowest inter-island crossing. Using GLOBETROTTER we detected Irish admixture signals from Britain and Europe and estimated dates for events consistent with the historical migrations of the Norse-Vikings, the Anglo-Normans and the British Plantations. The influence of the former is greater than previously estimated from Y chromosome haplotypes. In all, we paint a new picture of the genetic landscape of Ireland, revealing structure which should be considered in the design of studies examining rare genetic variation and its association with traits.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Russell L McLaughlin, Daniel G Bradley, Orla Hardiman, Garrett Hellenthal, Matthew Carrigan, Lara M Cassidy, Rui Martiniano, Ross P Byrne

Experts in our system

1
Russell L McLaughlin
Trinity College Dublin
Total Publications: 41
 
2
Daniel Bradley
Trinity College Dublin
Total Publications: 84
 
3
Orla Hardiman
Trinity College Dublin
Total Publications: 156
 
4
Matthew Carrigan
Trinity College Dublin
Total Publications: 7
 
5
Lara M Cassidy
Trinity College Dublin
Total Publications: 8
 
6
Rui Martiniano
Trinity College Dublin
Total Publications: 8