Type

Journal Article

Authors

Joanne Lysaght
John V Reynolds
Cliona O'Farrelly
Narayanasamy Ravi
Justin G Geoghegan
Derek G Doherty
Katie E O'Sullivan
Emma Foley
Ronan Fahey
Margaret R Dunne
and 3 others

Subjects

Veterinary

Topics
liver obesity inflammation t cells inflammatory cytokine cancer treatment adenocarcinoma incidence

Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma. (2017)

Abstract Checkpoint inhibitors, such as anti-PD-1 (Programmed death-1), are transforming cancer treatment for inoperable or advanced disease. As the incidence of obesity-associated malignancies, including esophageal adenocarcinoma (EAC) continues to increase and treatment with checkpoint inhibitors are being FDA approved for a broader range of cancers, it is important to assess how anti-PD-1 treatment might exacerbate pre-existing inflammatory processes at other sites. Outside the EAC tumor, the omentum and liver were found to be enriched with substantial populations of PD-1 expressing T cells. Treatment of omental and hepatic T cells with anti-PD-1 (clone EH12.2H7) did not enhance inflammatory cytokine expression or proliferation, but transiently increased CD107a expression by CD8
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Joanne Lysaght, John V Reynolds, Cliona O'Farrelly, Narayanasamy Ravi, Justin G Geoghegan, Derek G Doherty, Katie E O'Sullivan, Emma Foley, Ronan Fahey, Margaret R Dunne and 3 others

Experts in our system

1
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
 
2
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
3
Cliona O'Farrelly
Trinity College Dublin
Total Publications: 147
 
4
N Ravi
Trinity College Dublin
Total Publications: 61
 
5
Justin Geoghegan
Trinity College Dublin
Total Publications: 14
 
6
Derek Doherty
Trinity College Dublin
Total Publications: 52
 
7
Katie E O'Sullivan
Trinity College Dublin
 
8
Ronan Fahey
Trinity College Dublin
Total Publications: 5
 
9
Margaret R Dunne
Trinity College Dublin
Total Publications: 22