Type

Journal Article

Authors

Robert Whelan
Clare Kelly
Hugh Garavan
Gunter Schumann
Henrik Walter
Michael N Smolka
Tomas Paus
Dimitri Papadopoulos Orfanos
Frauke Nees
Bernd Ittermann
and 19 others

Subjects

Psychiatry

Topics
adhd reaction time neural circuitry data analysis attention neuroscience functional connectivity stop signal task reaction time variablity attention deficit hyperactivity disorder adhd neural networks motor cortex mental health psychosocial disability sustained attention fmri health

Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology. (2017)

Abstract Moment-to-moment reaction time variability on tasks of attention, often quantified by intra-individual response variability (IRV), provides a good indication of the degree to which an individual is vulnerable to lapses in sustained attention. Increased IRV is a hallmark of several disorders of attention, including Attention-Deficit/Hyperactivity Disorder (ADHD). Here, task-based fMRI was used to provide the first examination of how average brain activation and functional connectivity patterns in adolescents are related to individual differences in sustained attention as measured by IRV. We computed IRV in a large sample of adolescents (n = 758) across 'Go' trials of a Stop Signal Task (SST). A data-driven, multi-step analysis approach was used to identify networks associated with low IRV (i.e., good sustained attention) and high IRV (i.e., poorer sustained attention). Low IRV was associated with greater functional segregation (i.e., stronger negative connectivity) amongst an array of brain networks, particularly between cerebellum and motor, cerebellum and prefrontal, and occipital and motor networks. In contrast, high IRV was associated with stronger positive connectivity within the motor network bilaterally and between motor and parietal, prefrontal, and limbic networks. Consistent with these observations, a separate sample of adolescents exhibiting elevated ADHD symptoms had increased fMRI activation and stronger positive connectivity within the same motor network denoting poorer sustained attention, compared to a matched asymptomatic control sample. With respect to the functional connectivity signature of low IRV, there were no statistically significant differences in networks denoting good sustained attention between the ADHD symptom group and asymptomatic control group. We propose that sustained attentional processes are facilitated by an array of neural networks working together, and provide an empirical account of how the functional role of the cerebellum extends to cognition in adolescents. This work highlights the involvement of motor cortex in the integrity of sustained attention, and suggests that atypically strong connectivity within motor networks characterizes poor attentional capacity in both typically developing and ADHD symptomatic adolescents.
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Full list of authors on original publication

Robert Whelan, Clare Kelly, Hugh Garavan, Gunter Schumann, Henrik Walter, Michael N Smolka, Tomas Paus, Dimitri Papadopoulos Orfanos, Frauke Nees, Bernd Ittermann and 19 others

Experts in our system

1
Robert Whelan
Trinity College Dublin
Total Publications: 80
 
2
Clare Kelly
Trinity College Dublin
Total Publications: 7
 
3
Hugh Garavan
Trinity College Dublin
Total Publications: 170
 
4
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
5
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
6
Tomas Paus
Trinity College Dublin
Total Publications: 62
 
7
Frauke Nees
Trinity College Dublin
Total Publications: 63