Journal Article


Mark A Bellgrove
Jason B Mattingley
Redmond G O'Connell
Angela J Dean
Natasha Matthews
Inga Laube



processing brain controlled study suppression receptors muscarinic influence double blind scopolamine

Scopolamine Reduces Electrophysiological Indices of Distractor Suppression: Evidence from a Contingent Capture Task. (2017)

Abstract Limited resources for the in-depth processing of external stimuli make it necessary to select only relevant information from our surroundings and to ignore irrelevant stimuli. Attentional mechanisms facilitate this selection via top-down modulation of stimulus representations in the brain. Previous research has indicated that acetylcholine (ACh) modulates this influence of attention on stimulus processing. However, the role of muscarinic receptors as well as the specific mechanism of cholinergic modulation remains unclear. Here we investigated the influence of ACh on feature-based, top-down control of stimulus processing via muscarinic receptors by using a contingent capture paradigm which specifically tests attentional shifts toward uninformative cue stimuli which display one of the target defining features In a double-blind, placebo controlled study we measured the impact of the muscarinic receptor antagonist
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Mark A Bellgrove, Jason B Mattingley, Redmond G O'Connell, Angela J Dean, Natasha Matthews, Inga Laube

Experts in our system

Mark A. Bellgrove
Trinity College Dublin
Total Publications: 39
Redmond G O'Connell
Trinity College Dublin
Total Publications: 59