Type

Journal Article

Authors

Hugh Garavan
Luke Clancy
Jennifer Jones
Ella McCabe
Liam J Nestor

Subjects

Psychiatry

Topics
drug processing outcomes anterior cingulate cortex smoking cessation operant reactivity current

Shared and divergent neural reactivity to non-drug operant response outcomes in current smokers and ex-smokers. (2017)

Abstract Addiction to cigarettes presents with considerable health risks and induces high costs on healthcare resources. While the majority of cigarette smokers endorse the desire to quit, only a small percentage of quit attempts lead to full abstinence. Failure to achieve abstinence may arise from maladaptive reactivity in fronto-striatal regions that track positive and negative valence outcomes, thus biasing the choice to smoke in the presence of alternative, non-drug reinforcement. Alternatively, long-term nicotine abstinence may reveal neural substrates of adaptive valence outcome processing that promote and maintain smoking cessation. The present study set out to examine the neural correlates of operant response outcomes in current smokers, ex-smokers and matched controls using a monetary incentive delay task during functional MRI. Here we report that compared to controls, both current smokers and ex-smokers showed significantly less activation change in the left amygdala during positive response outcomes, and in the anterior cingulate cortex, during both positive and negative response outcomes. Ex-smokers, however, demonstrated significantly greater activation change compared to smokers and controls in the right amygdala during negative response outcomes. Activation change in the anterior cingulate cortex and middle frontal gyrus of smokers was significantly negatively correlated with nicotine dependence and cigarette pack-years. These results suggest a pattern of shared and divergent reactivity in current smokers and ex-smokers within corticolimbic regions that track both positive and negative operant response outcomes. Exaggerated adaptive processing in ex-smokers may promote long-term smoking cessation through amplified negative valence outcome monitoring.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Hugh Garavan, Luke Clancy, Jennifer Jones, Ella McCabe, Liam J Nestor

Experts in our system

1
Hugh Garavan
Trinity College Dublin
Total Publications: 160
 
2
Luke Clancy
Trinity College Dublin
Total Publications: 3
 
3
Jennifer Jones
Trinity College Dublin
Total Publications: 4
 
4
Ella McCabe
Trinity College Dublin
Total Publications: 3
 
5
Liam Nestor
Trinity College Dublin
Total Publications: 7