Type

Journal Article

Authors

Lorraine O'Driscoll
John Crown
Aled Clayton
Susan Breslin
Josephine Salimu
Sadhbh O'Neill
Vanesa G Martinez

Subjects

Medicine & Nursing

Topics
extracellular vesicles cancer cells breast cancer exosomes biomarker patients cancer neuromedin u neo adjuvant clinical trial immune evasion resistance her2 anti cancer drugs her2 positive

Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles. (2017)

Abstract Neuromedin U (NmU) -a neuropeptide belonging to the neuromedin family- plays a substantial role in HER2-positive breast cancer, correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall significantly poorer outcome for patients. However, the mechanism through which it exerts these effects remains unclear. To elucidate this, initially we used HER2-positive breast cancer cells stably over-expressing NmU. These cells and their released extracellular vesicles (EVs) had increased amounts of the immunosuppressive cytokine TGFβ
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Full list of authors on original publication

Lorraine O'Driscoll, John Crown, Aled Clayton, Susan Breslin, Josephine Salimu, Sadhbh O'Neill, Vanesa G Martinez

Experts in our system

1
Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 164
 
2
John Crown
Dublin City University
Total Publications: 104
 
3
Susan Breslin
Trinity College Dublin
Total Publications: 8
 
4
Sadhbh O'Neill
Trinity College Dublin
 
5
Vanesa G Martinez
Trinity College Dublin
Total Publications: 8