Journal Article


Todd Lencz
Anil K Malhotra
David C Glahn
Ian J Deary
Ole A Andreassen
Matthew C Keller
Stephanie Le Hellard
Jari Lahti
Dan Rujescu
Panos Bitsios
and 55 others



drug analysis an intellectual disability tissue analysis meta analysis neural tissue genome wide association study large scale educational attainment

Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. (2017)

Abstract Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability ("g"), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated with general cognitive ability. Results showed significant enrichment for genes causing Mendelian disorders with an intellectual disability phenotype. Competitive pathway analysis implicated the biological processes of neurogenesis and synaptic regulation, as well as the gene targets of two pharmacologic agents: cinnarizine, a T-type calcium channel blocker, and LY97241, a potassium channel inhibitor. Transcriptome-wide and epigenome-wide analysis revealed that the implicated loci were enriched for genes expressed across all brain regions (most strongly in the cerebellum). Enrichment was exclusive to genes expressed in neurons but not oligodendrocytes or astrocytes. Finally, we report genetic correlations between cognitive ability and disparate phenotypes including psychiatric disorders, several autoimmune disorders, longevity, and maternal age at first birth.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Todd Lencz, Anil K Malhotra, David C Glahn, Ian J Deary, Ole A Andreassen, Matthew C Keller, Stephanie Le Hellard, Jari Lahti, Dan Rujescu, Panos Bitsios and 55 others

Experts in our system

Dan Rujescu
Trinity College Dublin
Total Publications: 21