Journal Article


Katerina Dvorak
John V Reynolds
Naoimh J O'Farrell
Claire L Donohoe
Katherine S Garman
Rhonda F Souza
Kiron M Das
Amit Verma
Manisha Bajpai
Xiaoxin Chen
and 1 others



humans pathology metabolism barrett esophagus esophageal neoplasms adenocarcinoma cell transformation neoplastic animals genetics dna methylation disease models animal biomarkers tumor

Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma. (2013)

Abstract This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Katerina Dvorak, John V Reynolds, Naoimh J O'Farrell, Claire L Donohoe, Katherine S Garman, Rhonda F Souza, Kiron M Das, Amit Verma, Manisha Bajpai, Xiaoxin Chen and 1 others

Experts in our system

J V Reynolds
Trinity College Dublin
Total Publications: 206
N J O'Farrell
Trinity College Dublin
Total Publications: 14
Claire L Donohoe
Trinity College Dublin
Total Publications: 38