Type

Report

Authors

Paul M Dockree
Niall P Pender
Michael Marnane
Conor Fearon
Joshua H Balsters
Tim Lynch
Ian H Robertson
Simona Salomone

Subjects

Microbiology

Topics
memory disorders pathology complications autoimmune diseases physiopathology cognition disorders etiology coma brain male young adult physiology humans adult attention medulla oblongata brain diseases female immunology

The effects of immunologic brainstem encephalopathy on cognitive function following awakening from a progressive autoimmune coma. (2013)

Abstract We describe a unique patient who experienced a progressive autoimmune coma from age 14 to 17. The patient awoke after treatment with immunosuppressant medication. Although alertness, verbalization, and mobilization markedly improved, the patient reported persistent cognitive difficulties. Neuropsychological assessment from age 21 showed impairments in selective attention, distractibility, and memory. Conversely, higher-order executive functions were preserved. Electrophysiological analysis also identified abnormal neural signatures of selective attention. Eighteen months after the neuropsychological assessment, voxel-based morphometry revealed reduced white matter in the medulla compared to controls. The findings are discussed in terms of the impact of brainstem encephalopathy on cognitive mechanisms.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Paul M Dockree, Niall P Pender, Michael Marnane, Conor Fearon, Joshua H Balsters, Tim Lynch, Ian H Robertson, Simona Salomone

Experts in our system

1
Paul M Dockree
Trinity College Dublin
Total Publications: 32
 
2
Niall Pender
Trinity College Dublin
Total Publications: 7
 
3
Michael Marnane
Royal College of Surgeons in Ireland
Total Publications: 4
 
4
Conor Fearon
Dublin Institute of Technology
Total Publications: 5
 
5
Joshua Balsters
Trinity College Dublin
Total Publications: 23
 
6
Tim Lynch
University College Dublin
Total Publications: 12
 
7
Ian H Robertson
Trinity College Dublin
Total Publications: 142
 
8
Simona Salomone
Trinity College Dublin
Total Publications: 5