Journal Article


D M Murphy
J MacSharry
J. Galvin
A. Sullivan
E B Hunt


Medicine & Nursing

clinical inflammatory response pulmonary disorders inflammation epithelial cells individual experimental models acute lung injury

Gastric Aspiration and Its Role in Airway Inflammation. (2017)

Abstract Gastro-Oesophageal Reflux (GOR) has been associated with chronic airway diseases while the passage of foreign matter into airways and lungs through aspiration has the potential to initiate a wide spectrum of pulmonary disorders. The clinical syndrome resulting from such aspiration will depend both on the quantity and nature of the aspirate as well as the individual host response. Aspiration of gastric fluids may cause damage to airway epithelium, not only because acidity is toxic to bronchial epithelial cells but also due to the effect of digestive enzymes such as pepsin and bile salts. Experimental models have shown that direct instillation of these factors to airways epithelia cause damage with a consequential inflammatory response. The pathophysiology of these responses is gradually being dissected, with better understanding of acute gastric aspiration injury, a major cause of acute lung injury, providing opportunities for therapeutic intervention and potentially, ultimately, improved understanding of the chronic airway response to aspiration. Ultimately, clarification of the inflammatory pathways which are related to micro-aspiration
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

D M Murphy, J MacSharry, J. Galvin, A. Sullivan, E B Hunt

Experts in our system

Desmond M. Murphy
University College Cork
Total Publications: 30
John MacSharry
University College Cork
Total Publications: 40
J. Galvin
University College Cork
Total Publications: 3
Ashley Sullivan
University College Cork
Total Publications: 5
Eoin Hunt
University College Cork
Total Publications: 13