Type

Journal Article

Authors

Anne P Nugent
Michael J Gibney
Janette Walton
Albert Flynn
Breige A McNulty
Dan J Duff
Jack F Bloomfield
Lorraine Brennan
Kaifeng Li

Subjects

Physiotherapy & Sport

Topics
body fat fatty acids national nutrition survey blood pressure waist circumference linoleic acid insulin resistance irish adults

Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults. (2017)

Abstract This study examines to what extent plasma linoleic acid (LA) is modified by adiposity, and explores any association between plasma LA, demographics, dietary intakes, markers of metabolic health, and haplotypes of the fatty acid desaturase (FADS) 1/2 genes. A total of 820 participants with fasting blood samples from the Irish National Adult Nutrition Survey are studied. Plasma fatty acids are determined using GC-MS. Fifteen SNPs of FADS 1/2 genes are genotyped. Plasma LA decreases, while γ-linoleic acid and dihomo-γ-linoleic acid increases in overweight/obese participants (p ≤ 0.002). Participants in the highest quartile of plasma LA show decreased plasma markers of de novo lipogenesis, insulin resistance, and of inflammation (TNF-α, PAI-1) (p ≤ 0.005). Adiposity (waist circumference and body fat) is strongly inversely associated with plasma LA accounting for 11.8% of variance observed, which is followed by FADS1/2 haplotypes (3.9%), quantity and quality of carbohydrate intakes (3.8%), dietary PUFA intakes (3.7%), systolic blood pressure (3.6%), and age (3.2%). Plasma LA is inversely associated with adiposity, followed by haplotypes of FADS1/2 genes, carbohydrate intakes, and dietary PUFA intakes. The association observed between plasma LA and adiposity may be linked to decreased de novo lipogenesis, insulin resistance, and inflammation.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Anne P Nugent, Michael J Gibney, Janette Walton, Albert Flynn, Breige A McNulty, Dan J Duff, Jack F Bloomfield, Lorraine Brennan, Kaifeng Li

Experts in our system

1
Anne P Nugent
University College Cork
 
2
Michael J Gibney
University College Dublin
Total Publications: 102
 
3
Janette Walton
University College Cork
Total Publications: 79
 
4
Albert Flynn
University College Cork
Total Publications: 83
 
5
Breige A McNulty
University College Cork
 
6
Dan J Duff
University College Cork
 
7
Jack F Bloomfield
University College Cork
 
8
Lorraine Brennan
University College Dublin
Total Publications: 166
 
9
Kaifeng Li
University College Cork