Type

Journal Article

Authors

Colin Hill
Amanda Forde

Subjects

Medicine & Nursing

Topics
world health organization antibiotic resistance this review therapy human health patient focused phages life

Phages of life - the path to pharma. (2017)

Abstract Bacteriophage (phage) therapy has encountered both enthusiasm and scepticism in the past century. New antimicrobial strategies against lethal pathogens are now a top priority for the World Health Organization, and although compassionate use of phages recently met with significant success, regulated clinical interventions seem unlikely in the near future. The hundredth anniversary of their discovery seems an appropriate time for a revival of phage therapy, particularly as the dilemma of antibiotic resistance grows. Phages are ubiquitous in the environment, on our food and in and on our bodies. Their influence on human health is currently being evaluated, and in this mini-review, we examine data from recent metagenomic studies that propose a role for phages in the structure of the microbiome and in health and disease. We assess evidence for phages as vehicles for gene transfer in the context of antibiotic resistance and discuss challenges and opportunities along the critical path from phage discovery to a patient-focused pharmaceutical intervention.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Colin Hill, Amanda Forde

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
Amanda Forde
University College Cork
Total Publications: 3