Type

Journal Article

Authors

John Crown
Naoise C Synnott
Michael J Duffy

Subjects

Medicine & Nursing

Topics
triple negative breast cancer retrospective studies cancer treatment anticancer activity therapeutic mutant biomarker

Mutant p53 in breast cancer: potential as a therapeutic target and biomarker. (2018)

Abstract The aim of this article is to discuss mutant p53 as a possible therapeutic target and biomarker for breast cancer. TP53 (p53) is the most frequently mutated gene in invasive breast cancer. Although mutated in 30-35% of all cases, p53 is mutated in approximately 80% of triple-negative (TN) tumors (i.e., tumors negative for ER, PR, and HER2). Because of this high prevalence, mutated p53 is both a potential biomarker and therapeutic target for patients with breast cancer, especially for those with the TN subtype. Although several retrospective studies have investigated a potential prognostic and therapy predictive role for mutant p53 in breast cancer, the results to date are mixed. Thus, at present, mutant p53 cannot be recommended as a prognostic or therapy predictive biomarker in breast cancer. In contrast to the multiple reports on a potential biomarker role, few studies had until recently, investigated mutant p53 as a potential target for breast cancer treatment. In the last decade, however, several compounds have become available which can reactivate mutant p53 protein and convert it to a conformation with wild-type properties. Some of these compounds, especially PRIMA-1, APR-246 PK11007, and COTI-2, have been found to exhibit anticancer activity in preclinical models of breast cancer. Since p53 is mutated in the vast majority of TN breast cancers, compounds such as APR-246, PK11007, and COTI-2 are potential treatments for patients with this subform of the disease. Further research is necessary to identify a potential biomarker role for mutant p53 in breast cancer.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

John Crown, Naoise C Synnott, Michael J Duffy

Experts in our system

1
John Crown
Dublin City University
Total Publications: 104
 
2
Naoise C Synnott
Dublin City University
 
3
Michael J Duffy
University College Dublin